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High-fat diet augments ovariectomy-induced bone resorption in rats / Dieta rica en grasas aumenta la resorción ósea inducida por ovariectomía en ratas
El-Bidawy, Mahmoud H; Bastawy, Nermeen; Mansour-Khalifa, Mohamed; Abdulla, Hanan; Elsayed, Rania; Rashed, Laila; Niazy, Marwa; Al-Ghamdi, Sameer; Haidara, Mohamed A.
  • El-Bidawy, Mahmoud H; Prince Sattam Ibn Abdulaziz University. College of Medicine. Division of physiology. Al-Kharj. SA
  • Bastawy, Nermeen; Cairo University. Faculty of Medicine. Departments of Medical Physiology. EG
  • Mansour-Khalifa, Mohamed; Cairo University. Faculty of Medicine. Departments of Medical Physiology. EG
  • Abdulla, Hanan; Cairo University. Faculty of Medicine. Histology and Cell Biology. EG
  • Elsayed, Rania; Cairo University. Faculty of Medicine. Biochemistry. EG
  • Rashed, Laila; Cairo University. Faculty of Medicine. Biochemistry. EG
  • Niazy, Marwa; Cairo University. Faculty of Medicine. Rheumatology and Rehabilitation. EG
  • Al-Ghamdi, Sameer; Prince Sattam Ibn Abdulaziz University. College of Medicine. Division of Family Medicine. Al-Kharj. SA
  • Haidara, Mohamed A; King Khalid University. College of Medicine. Department of Physiology. Abha. SA
Int. j. morphol ; 38(1): 129-134, Feb. 2020. tab, graf
Article in English | LILACS | ID: biblio-1056410
Responsible library: CL1.1
ABSTRACT
Menopause complications such as cardiovascular and bone diseases represent a major public health concern. We sought to determine whether a high-fat diet (HFD) can augment ovariectomy-induced bone resorption in a rat model of menopause possibly via the upregulation of the inflammatory biomarkers and dyslipidemia. Rats were either ovariectomized and fed a standard laboratory chow (model group) or were ovariectomized and fed with a HFD for 15 weeks before being sacrificed. Ovariectomy significantly (p<0.05) increased body weight, dyslipidemia, insulin resistance, pro-inflammatory cytokines tumor necrosis factor-a (TNF-α) and interleukin-6 (IL-6), and biomarker of bone resorption, nuclear factor-kB (NF-kB), which were augmented by feeding animals with a HFD. This was confirmed through immunohistochemical study, where ovariectomy induced expression of p65/NF-kB protein in tibia bone sections of the model group, which were augmented by HFD. HFD augments ovariectomy-induced bone resorption through increased inflammatory biomarkers and NF-kB in rats.
RESUMEN
Las complicaciones de la menopausia, como las enfermedades cardiovasculares y óseas, representan un importante problema de salud pública. Intentamos determinar si una dieta alta en grasas (HFD) puede aumentar la resorción ósea inducida por ovariectomía en un modelo de menopausia en ratas, a través de la regulación positiva de los biomarcadores inflamatorios y la dislipidemia. Las ratas fueron ovariectomizadas y alimentadas con una comida estándar de laboratorio (grupo modelo) o fueron ovariectomizadas y alimentadas con un HFD durante 15 semanas antes de ser sacrificadas. La ovariectomía aumentó significativamente (p <0,05) el peso corporal, dislipidemia, resistencia a la insulina, citocinas proinflamatorias, factor de necrosis tumoral a (TNF-α) e interleucina-6 (IL-6), y el biomarcador de resorción ósea, factor nuclear-kB (NF-kB), que se aumentaron alimentando animales con un HFD. Esto se confirmó a través del estudio inmunohistoquímico, donde la ovariectomía indujo la expresión de la proteína p65 / NF-kB en secciones de hueso de tibia del grupo modelo, que fueron aumentadas por HFD. HFD aumenta la resorción ósea inducida por ovariectomía a través del aumento de biomarcadores inflamatorios y NF-kB en ratas.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Bone Resorption / Diet, High-Fat Type of study: Etiology study / Prognostic study Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2020 Type: Article Affiliation country: Egypt / Saudi Arabia Institution/Affiliation country: Cairo University/EG / King Khalid University/SA / Prince Sattam Ibn Abdulaziz University/SA

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Full text: Available Index: LILACS (Americas) Main subject: Bone Resorption / Diet, High-Fat Type of study: Etiology study / Prognostic study Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2020 Type: Article Affiliation country: Egypt / Saudi Arabia Institution/Affiliation country: Cairo University/EG / King Khalid University/SA / Prince Sattam Ibn Abdulaziz University/SA