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Prenatal stress up-regulated hippocampal glucocorticoid receptor expression in female adult rat offspring / Estrés prenatal expresión del receptor de glucocorticoides del hipocampo regulado por aumento en crías de ratas hembras adultas
Liao, Libin; Yao, Xueping; Huang, Jufang; Bai, Shengbin.
  • Liao, Libin; Xinjiang Medical University. Basic Medical College. Department of Histology and Embryology. Ürümqi. CN
  • Yao, Xueping; Xinjiang Medical University. Basic Medical College. Department of Mechanism Lab Centre. Ürümqi. CN
  • Huang, Jufang; Central South University. School of Basic Medical Sciences. Department of Anatomy and Neurobiology. Changsha. CN
  • Bai, Shengbin; Xinjiang Medical University. Basic Medical College. Department of Histology and Embryology. Ürümqi. CN
Int. j. morphol ; 38(2): 400-405, abr. 2020. graf
Article in English | LILACS | ID: biblio-1056454
ABSTRACT
Accumulating evidence from preclinical and clinical studies indicates prenatal exposure to stress or excess glucocorticoids can affect offspring brain. Glucocorticoid receptor (GR) is an important target of glucocorticoid. Therefore the aim of the present study was to investigate the expression of GR in prenatally stressed adult offspring and the relationship between GR expression and behavior in offspring. Pregnant rats received restraint stress during the last week of pregnancy. Hippocampal glucocorticoid receptor expression levels in the offspring were detected on postnatal 60 (P60).Cognition function was also detected. It shows significantly lower hippocampal GR expression was observed in female prenatally stressed offspring compared with their controls at P60. Corresponding to the expression of GR, female prenatally stressed offspring exhibited poorer spatial learning and memory abilities in the Barnes maze than control, This suggests that cognitive impairment in prenatally stressed rat offspring attribute lower hippocampal GR expression.
RESUMEN
La evidencia acumulada de estudios preclínicos y clínicos indica que la exposición prenatal al estrés, o el exceso de glucocorticoides puede afectar el desarrollo cerebral de las crías. El receptor de glucocorticoides (RG) es un objetivo importante de los glucocorticoides. Por lo tanto, el objetivo del presente estudio fue investigar la expresión de RG en crías adultas estresadas durante el período prenatal y la relación entre la expresión de RG y el comportamiento de las crías. Las ratas preñadas recibieron niveles de estrés restringido, durante la última semana de embarazo. Se determinaron niveles de expresión del receptor de glucocorticoides del hipocampo y niveles de función cognitiva en las crías. En comparación con el grupo control se observó una expresión de RG en el hipocampo, significativamente menor en las crías estresadas prenatalmente, en comparación con los controles en P60. En referencia a la expresión de RG, las crías estresadas prenatalmente exhibieron habilidades de memoria y aprendizaje espacial menores, en el laberinto de Barnes que el grupo control. Esto sugiere que el deterioro cognitivo en crías de ratas estresadas prenatalmente muestran una menor expresión de RG en el hipocampo.
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Full text: Available Index: LILACS (Americas) Main subject: Prenatal Exposure Delayed Effects / Receptors, Glucocorticoid / Cognitive Dysfunction / Hippocampus Limits: Animals / Pregnancy Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2020 Type: Article Affiliation country: China Institution/Affiliation country: Central South University/CN / Xinjiang Medical University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Prenatal Exposure Delayed Effects / Receptors, Glucocorticoid / Cognitive Dysfunction / Hippocampus Limits: Animals / Pregnancy Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2020 Type: Article Affiliation country: China Institution/Affiliation country: Central South University/CN / Xinjiang Medical University/CN