Mycobacterium tuberculosis spoligotypes and drug-resistant characterization from Beira compared to genotypes circulating in Mozambique
Rev. Soc. Bras. Med. Trop
;
52: e20190257, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1057252
ABSTRACT
Abstract INTRODUCTION Mozambique is one of three countries with high prevalence of tuberculosis (TB), TB/human immunodeficiency virus coinfection, and multidrug-resistant TB. We aimed to describe Mycobacterium tuberculosis spoligotypes circulating among drug resistant (DR) strains from Beira, Mozambique comparing them with genotypes in the country. METHODS:
We performed spoligotyping of 79 M. tuberculosis suspected of DR-TB compared all spoligotype patterns published on the international database and PubMed.RESULTS:
Both in Beira and Mozambique (n=578), the main clades were Latin-American-Mediterranean, East-African-Indian, Beijing and T, with no extensively DR TB cases.CONCLUSIONS:
Beira and Mozambique share the same population genetic structure of M. tuberculosis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Genetic Variation
/
Tuberculosis, Multidrug-Resistant
/
Mycobacterium tuberculosis
Type of study:
Risk factors
Limits:
Humans
Country/Region as subject:
Africa
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2019
Type:
Article
Affiliation country:
Brazil
/
France
Institution/Affiliation country:
Universidade Federal de Minas Gerais/BR
/
Universidade Federal do Rio de Janeiro/BR
/
Universidade de São Paulo/BR
/
Université Paris-Saclay/FR
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