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Demographic and clinical characteristics of pulmonary arterial hypertension caused by schistosomiasis are indistinguishable from other etiologies
Mendes, Adriano Assis; Roncal, Carlos Guilhermo Piscoya; Oliveira, Flávio Roberto Azevedo de; Albuquerque, Eugênio Soares de; Góes, Gustavo Henrique Belarmino; Piscoya, Isabelle Cecília de Vasconcellos; Sobral Filho, Dário Celestino.
  • Mendes, Adriano Assis; Universidade de Pernambuco. Pronto-Socorro Cardiológico de Pernambuco. Departamento de Hipertensão Pulmonar. Recife. BR
  • Roncal, Carlos Guilhermo Piscoya; Universidade de Pernambuco. Pronto-Socorro Cardiológico de Pernambuco. Departamento de Hipertensão Pulmonar. Recife. BR
  • Oliveira, Flávio Roberto Azevedo de; Universidade de Pernambuco. Departamento de Hemodinâmica. Recife. BR
  • Albuquerque, Eugênio Soares de; Universidade de Pernambuco. Departamento de Ecocardiografia. Recife. BR
  • Góes, Gustavo Henrique Belarmino; Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife. BR
  • Piscoya, Isabelle Cecília de Vasconcellos; Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife. BR
  • Sobral Filho, Dário Celestino; Universidade de Pernambuco. Programa de Pós-Graduação em Ciências da Saúde. Recife. BR
Rev. Soc. Bras. Med. Trop ; 53: e20190418, 2020. tab, graf
Article in English | LILACS | ID: biblio-1057263
ABSTRACT
Abstract

INTRODUCTION:

Pulmonary arterial hypertension (PAH) is a serious pulmonary circulation disease caused by several etiologies, including schistosomiasis. The present study retrospectively evaluated the clinical and hemodynamic characteristics of patients with schistosomal PAH (PAH-Sch) compared to those of non-Sch PAH patients (non-Sch PAH).

METHODS:

Patients treated at the Pronto-Socorro Cardiológico de Pernambuco and diagnosed by right cardiac catheterization were divided into PAH-Sch and non-Sch PAH groups. Their socio-demographic and clinical characteristics, N-terminal-pro B-type natriuretic peptide (NT-proBNP), and echocardiography and hemodynamic parameters were retrospectively reviewed.

RESULTS:

Among the included 98 patients (mean age, 45 ± 14 years; 68 women [69.4%]), we found 56 PAH-Sch and 42 non-Sch PAH. The age distribution was heterogeneous in the PAH-Sch group, with patients predominantly ranging from 50-59 (p <0.004). Dyspnea was the most common symptom, reported by 92 patients (93.8%), and commonly present for over two years prior to diagnosis. Clinical symptoms were similar in both groups, with no differences in functional class, pulmonary artery systolic pressure (p = 0.102), 6-minute walk test score (p = 0.234), NT-proBNP serum levels (p = 0.081), or hemodynamic parameters.

CONCLUSIONS:

Patients with PAH-Sch present clinical, laboratory, and hemodynamic profiles similar to those with PAH resulting from other etiologies of poor prognosis. PAH is an important manifestation of schistosomiasis in endemic regions that is often diagnosed late.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Protein Precursors / Schistosomiasis / Atrial Natriuretic Factor / Pulmonary Arterial Hypertension Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Pernambuco/BR

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Full text: Available Index: LILACS (Americas) Main subject: Protein Precursors / Schistosomiasis / Atrial Natriuretic Factor / Pulmonary Arterial Hypertension Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Pernambuco/BR