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Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil
Gontijo, Maria Katarine Costa Lucas; Arruda, Hilda Maria Benevides da Silva de; Noronha, Elza Ferreira; Toledo, Maria Inês de.
  • Gontijo, Maria Katarine Costa Lucas; Universidade de Brasília. Faculdade de Ciências da Saúde. Brasília. BR
  • Arruda, Hilda Maria Benevides da Silva de; Hospital Universitário de Brasília. Brasília. BR
  • Noronha, Elza Ferreira; Hospital Universitário de Brasília. Brasília. BR
  • Toledo, Maria Inês de; Universidade de Brasília. Faculdade de Ciências da Saúde. Brasília. BR
Rev. Soc. Bras. Med. Trop ; 53: e20190150, 2020. tab
Article in English | LILACS | ID: biblio-1057268
ABSTRACT
Abstract

INTRODUCTION:

Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil's Federal District.

METHODS:

Medical records were analyzed and ADRs were categorized by type, intensity, seriousness, and causality.

RESULTS:

Of the 62 patients who started benznidazole treatment for CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued the treatment. Most reactions were classified as probable (81%), severe (63%), serious (67%), and dose-dependent (56%).

CONCLUSIONS:

The high incidence of ADRs because of treatment withdrawal revealed the need for safer alternatives for CD treatment.
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Full text: Available Index: LILACS (Americas) Main subject: Trypanocidal Agents / Chagas Disease / Drug-Related Side Effects and Adverse Reactions / Nitroimidazoles Type of study: Incidence study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Universitário de Brasília/BR / Universidade de Brasília/BR

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Full text: Available Index: LILACS (Americas) Main subject: Trypanocidal Agents / Chagas Disease / Drug-Related Side Effects and Adverse Reactions / Nitroimidazoles Type of study: Incidence study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Universitário de Brasília/BR / Universidade de Brasília/BR