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Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil
Polotto, Milena; Casella, Tiago; Tolentino, Fernanda Modesto; Mataruco, Mayra Mioto; Porto, Naiady Konno Madela; Binhardi, Mirella Fontana Batista; Nogueira, Mara Corrêa Lelles.
  • Polotto, Milena; Instituto Adolfo Lutz. Centro de Laboratório Regional de São José do Rio Preto. São José do Rio Preto. BR
  • Casella, Tiago; Faculdade de Medicina de São José do Rio Preto. Centro de Investigação de Microrganismos. São José do Rio Preto. BR
  • Tolentino, Fernanda Modesto; Instituto Adolfo Lutz. Centro de Laboratório Regional de São José do Rio Preto. São José do Rio Preto. BR
  • Mataruco, Mayra Mioto; Universidade Federal de São Carlos. São Carlos. BR
  • Porto, Naiady Konno Madela; Faculdade de Medicina de São José do Rio Preto. Centro de Investigação de Microrganismos. São José do Rio Preto. BR
  • Binhardi, Mirella Fontana Batista; Instituto Adolfo Lutz. Centro de Laboratório Regional de São José do Rio Preto. São José do Rio Preto. BR
  • Nogueira, Mara Corrêa Lelles; Faculdade de Medicina de São José do Rio Preto. Centro de Investigação de Microrganismos. São José do Rio Preto. BR
Rev. Soc. Bras. Med. Trop ; 53: e20190044, 2020. tab
Article in English | LILACS | ID: biblio-1057279
ABSTRACT
Abstract

INTRODUCTION:

Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs).

METHODS:

Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital.

RESULTS:

The key genes found were bla OXA-51-like, the association ISAba1- bla OXA-23-like, and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards.

CONCLUSIONS:

The dissemination of bla OXA-23-like and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.
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Full text: Available Index: LILACS (Americas) Main subject: Bacterial Proteins / Beta-Lactamases / Acinetobacter Infections / Acinetobacter baumannii / Aminoglycosides Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina de São José do Rio Preto/BR / Instituto Adolfo Lutz/BR / Universidade Federal de São Carlos/BR

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Full text: Available Index: LILACS (Americas) Main subject: Bacterial Proteins / Beta-Lactamases / Acinetobacter Infections / Acinetobacter baumannii / Aminoglycosides Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina de São José do Rio Preto/BR / Instituto Adolfo Lutz/BR / Universidade Federal de São Carlos/BR