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Relationship between antifungal susceptibility profile and virulence factors in Candida albicans isolated from nail specimens
Mohammadi, Faezeh; Ghasemi, Zeinab; Familsatarian, Behnaz; Salehi, Eelham; Sharifynia, Somayeh; Barikani, Ameneh; mirzadeh, Monirsadat; Hosseini, Mohammad Ali.
  • Mohammadi, Faezeh; Qazvin university of Medical Science. Medical Microbiology Research Center. Qazvin. IR
  • Ghasemi, Zeinab; Medical Mycology of Razi Hospital. Tehran. IR
  • Familsatarian, Behnaz; Qazvin University of Medical Sciences. Cellular and Molecular Research Center. Qazvin. IR
  • Salehi, Eelham; Medical Mycology of Razi Hospital. Tehran. IR
  • Sharifynia, Somayeh; Shahid Beheshti University of Medical Sciences. Clinical Tuberculosis and Epidemiology Research Center. Tehran. IR
  • Barikani, Ameneh; Qazvin University of Medical Science. Children Growth Research Center. Qazvin. IR
  • mirzadeh, Monirsadat; Qazvin University of Medical Sciences. Metabolic Disease Research Center. Qazvin. IR
  • Hosseini, Mohammad Ali; Qazvin University of Medical Sciences. Student Research Committee. Qazvin. IR
Rev. Soc. Bras. Med. Trop ; 53: e20190214, 2020. tab, graf
Article in English | LILACS | ID: biblio-1057290
Responsible library: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

The aim of this study was to evaluate some virulence factors in Candida albicans isolates from patients with onychomycosis and determine the correlation between these factors and the antifungal resistance profile.

METHODS:

Seventy species of C. albicans were confirmed using polymerase chain reaction amplification of the HWP1 gene. According to the Clinical & Laboratory Standards Institute guidelines, the susceptibility profile of four antifungal agents was investigated, and the production of aspartyl protease, phospholipase, haemolysin, and biofilm was determined. The correlation between these profiles was also investigated.

RESULTS:

The isolates indicated different levels of resistance and production of virulence factors. Significant correlations were observed between the minimum inhibitory concentration (MIC) of fluconazole/itraconazole and biofilm production, between phospholipase production and fluconazole/itraconazole MIC, and between fluconazole MIC and hemolytic activity in C. albicans isolates. The results also showed significant correlations between phospholipase activity and biofilm production.

CONCLUSIONS:

Our findings will contribute to a better understanding of the pathogenesis of C. albicans and characterize the relationship between virulence factors and antifungal resistance, which may suggest new therapeutic strategies considering the possible involvement of the virulence mechanism in the effectiveness of treatment.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Candida albicans / Onychomycosis / Virulence Factors / Antifungal Agents / Nails Type of study: Practice guideline Limits: Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2020 Type: Article Affiliation country: Iran Institution/Affiliation country: Medical Mycology of Razi Hospital/IR / Qazvin University of Medical Science/IR / Qazvin University of Medical Sciences/IR / Qazvin university of Medical Science/IR / Shahid Beheshti University of Medical Sciences/IR

Full text: Available Index: LILACS (Americas) Main subject: Candida albicans / Onychomycosis / Virulence Factors / Antifungal Agents / Nails Type of study: Practice guideline Limits: Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2020 Type: Article Affiliation country: Iran Institution/Affiliation country: Medical Mycology of Razi Hospital/IR / Qazvin University of Medical Science/IR / Qazvin University of Medical Sciences/IR / Qazvin university of Medical Science/IR / Shahid Beheshti University of Medical Sciences/IR