Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C
Rev. Soc. Bras. Med. Trop
;
53: e20190210, 2020. tab
Article
in English
| LILACS
| ID: biblio-1057300
ABSTRACT
Abstract INTRODUCTION:
Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C.METHODS:
Patients (159) with chronic hepatitis C of both genders were analyzed.RESULTS:
Women showed association between HPA-3 polymorphisms and RM.CONCLUSIONS:
An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Rheumatic Diseases
/
Antigens, Human Platelet
/
Hepatitis C, Chronic
Type of study:
Etiology study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual Paulista/BR
Similar
MEDLINE
...
LILACS
LIS