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Effect of simulated geomagnetic activity on myocardial ischemia/reperfusion injury in rats
Wu, Hui; Chang, Weiyu; Deng, Yanglin; Chen, Xinli; Ding, Yongli; Li, Xuesong; Dong, Liang.
  • Wu, Hui; The First Affiliated Hospital of Kunming Medical University. Department of Pharmacy. Kunming. CN
  • Chang, Weiyu; The First Affiliated Hospital of Kunming Medical University. Department of Pharmacy. Kunming. CN
  • Deng, Yanglin; The First Affiliated Hospital of Kunming Medical University. Department of Pharmacy. Kunming. CN
  • Chen, Xinli; The First Affiliated Hospital of Kunming Medical University. Department of Pharmacy. Kunming. CN
  • Ding, Yongli; The First Affiliated Hospital of Kunming Medical University. Department of Pharmacy. Kunming. CN
  • Li, Xuesong; The First Affiliated Hospital of Kunming Medical University. Department of Pharmacy. Kunming. CN
  • Dong, Liang; Chinese Academy of Sciences. Yunnan Observatories. Kunming. CN
Rev. bras. cir. cardiovasc ; 34(6): 674-679, Nov.-Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1057497
Responsible library: BR1.1
ABSTRACT
Abstract

Objective:

To study the response of myocardial ischemia/reperfusion injury (MI/RI) in rats to simulated geomagnetic activity.

Methods:

In a simulated strong geomagnetic outbreak, the MI/RI rat models were radiated, and their area of myocardial infarction, hemodynamic parameters, creatine kinase (CK), lactate dehydrogenase (LDH), melatonin, and troponin I values were measured after a 24-hour intervention.

Results:

Our analysis indicates that the concentrations of troponin I in the geomagnetic shielding+operation group were lower than in the radiation+operation group (P<0.05), the concentrations of melatonin in the shielding+operation group and normal+operation group were higher than in the radiation + operation group (P<0.01), and the concentrations of CK in the shielding + operation group were lower than in the radiation + operation group and normal + operation group (P<0.05). Left ventricular developed pressure (LVDP) and ± dP/dtmax in the radiation+operation group were lower than in the shielding + operation group and normal+operation group (P<0.01). Left ventricular end-diastolic pressure (LEVDP) in the shielding + operation group was higher than in the normal + operation group (P<0.05). There was no significant difference in area of myocardial infarction and LDH between the shielding + operation group and the radiation + operation group.

Conclusion:

Our data suggest that geomagnetic activity is important in regulating myocardial reperfusion injury. The geomagnetic shielding has a protective effect on myocardial injury, and the geomagnetic radiation is a risk factor for aggravating the cardiovascular and cerebrovascular diseases.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Myocardial Reperfusion Injury / Magnetic Fields Type of study: Prognostic study / Risk factors Limits: Animals Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Chinese Academy of Sciences/CN / The First Affiliated Hospital of Kunming Medical University/CN

Full text: Available Index: LILACS (Americas) Main subject: Myocardial Reperfusion Injury / Magnetic Fields Type of study: Prognostic study / Risk factors Limits: Animals Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Chinese Academy of Sciences/CN / The First Affiliated Hospital of Kunming Medical University/CN