Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae
Rev. bras. farmacogn
;
29(6): 715-719, Nov.-Dec. 2019. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1057861
ABSTRACT
ABSTRACT Chemical investigation of the aqueous fraction of the ethanol extract from the Brazilian endemic marine sponge Clathria (Clathria) nicoleae Vieira de Barros, Santos & Pinheiro, 2013, Microcionidae, sampled from a 55 m deep rhodolith bed at the Amazon River mouth, led to the isolation of a new hexapeptide, clathriamide (1). HP-20 resin was used to capture compound 1 from the aqueous fraction, which was purified by additional chromatographic steps. The absolute configuration of the amino acids of 1 was determined by advanced Marfey's analysis using 5-fluoro-2,4-dinitrophenyl-Nα-L-tryptophanamide. The amino acid derivatives analyzed by ultra-performance liquid chromatography coupled to a mass spectrometry using a C8 column enabled a good chromatographic resolution of L-Ile and L-allo-Ile, previously unfeasible using C18 column.
Full text:
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Index:
LILACS (Americas)
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2019
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto de Pesquisas Jardim Botânico do Rio de Janeiro/BR
/
Instituto de Química de São Carlos/BR
/
Universidade Federal de São Carlos/BR
/
Universidade Federal do Rio de Janeiro/BR
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