Anemia hemolítica autoinmune en Chile: un análisis retrospectivo de 43 pacientes / Autoimmune hemolytic anemia: review of 43 cases
Rev. méd. Chile
; 147(7): 836-841, jul. 2019. tab, graf
Article
in Es
| LILACS
| ID: biblio-1058612
Responsible library:
CL1.1
ABSTRACT
Background:
Autoimmune hemolytic anemia (AIHA) is an uncommon disease. In its presentation, it can be severe and even lethal. There is only one clinical report concerning this pathology in Chile.Objective:
To describe the clinical characteristics and evolution of adult AIHA inpatients. Materials andMethods:
Retrospective review of clinical records of adult AIHA inpatients between January 2010 and June 2018 was done. Demographic, clinical, laboratory and therapeutic information was analyzed. A descriptive, analytical and survival analysis was performed.Results:
Forty-three adult patients diagnosed with AHIA were hospitalized in a period of 8 years. Median age was 63 years (range 22-86 years), mostly women (72%). Warm antibodies were detected in 36 cases (84%) and cold antibodies in seven. Seventy two percent of the patients had an underlying cause, and 58% were secondary to lymphoproliferative neoplasms. All patients except two, received steroids as initial treatment, with response in 37 (90%) of them. Three refractory patients received rituximab, with response in all of them, and relapse in one. Median follow-up was 38 months (range 2-98 months). Five year overall survival was 72%.Conclusion:
AHIA in adults inpatients is a heterogeneous disease, mainly due to warm antibodies, and to secondary etiology.Key words
Full text:
1
Index:
LILACS
Main subject:
Anemia, Hemolytic, Autoimmune
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
America do sul
/
Chile
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2019
Type:
Article