Patogenia comparada das cepas de micobactérias BCG e H37Rv em hamster (Mesocrisetus auratus): influência das vias sanguínea e linfática / Comparative pathogenesis of mycobacterial strains BCG and H37Rv in hamster (Mesocrisetus auratus): influence of blood and lymphatic pathways

Some aspects of the pathogeny of tuberculosis was experimentally investigated by inoculating either an attenuated mycobacteria strain BCG, or a virulent strainM. tuberculosis H37Rv into the foot pad or the cheek pouch of hamster. The inoculation of these agents determined different patterns of lesion. The BCG-induced lesionsin the foot pad had a tendency to descrease in size. On the other hand, the lesions induced by H37Rv showed a progressive evolution. The same pattern of evolution was observed with the lesions induced in the cheek pouch. However, the H37Rv disseminated to internal organs and the BCG did not. When BCG or H37Rv were inoculated in the foot pad of animals, the popliteal lymph node showed respectively a 21 fold and 68 fold increase in weight