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The protective effect of Ganoderma lucidum on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury
Doğan, Gül; İpek, Hülya.
  • Doğan, Gül; Hitit University. Faculty of Medicine. Department of Pediatric Surgery. Çorum. TR
  • İpek, Hülya; Hitit University. Erol Olcok Training and Research Hospital. Department of Pediatric Surgery. Çorum. TR
Acta cir. bras ; 35(1): e202000103, 2020. tab, graf
Article in English | LILACS | ID: biblio-1088520
ABSTRACT
Abstract Purpose To investigate the protective effect of Ganoderma lucidum on testicular torsion/detorsion (T/D)-induced ischemia-reperfusion (I/R) injury. Methods Thirty male Wistar albino rats were randomly categorized into 3 groups Group 1 sham, Group 2 ( T/D) 2,5 hours of ischemia and 7 days of reperfusion, Group 3 (T/D+ G. lucidum ) 2,5 hours of ischemia and 7 days of reperfusion and 7 days of 20 mg/kg via gastric gavage G. lucidum polysaccharides per day. Biochemical assays of Malondialdehyde (MDA), superoxide dismutase (SOD), Catalase (CAT), Glutathione (GSH) levels , histopathology and expression levels of VEGF and Bcl-2 with immunohistochemical methods were examined in testicular tissue. Results G. lucidum treatment was found to have prevented the T/D-induced I/R injury by decreasing MDA levels of the testis. SOD, CAT and GSH activities were decreased in group 2, while they were increased in group 3 (p<0.001) and significant improvement in the tube diameter was observed in group 3. Bcl-2-positive germinal cells were lowered in group 3 compared to the group 2. VEGF expression showed an increase in group 2, whereas it decreased in group 3. Conclusion The antioxidant G. lucidum is thought to induce angiogenesis by reducing the apoptotic effect in testicular torsion-detorsion.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Spermatic Cord Torsion / Testis / Reperfusion Injury / Reishi / Antioxidants Type of study: Etiology study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Hitit University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Spermatic Cord Torsion / Testis / Reperfusion Injury / Reishi / Antioxidants Type of study: Etiology study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Hitit University/TR