Guidelines of the Brazilian Society of Rheumatology for the treatment of systemic autoimmune myopathies
Adv Rheumatol
;
59: 6, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1088584
ABSTRACT
Abstract Background:
Recommendations of the Myopathy Committee of the Brazilian Society of Rheumatology for the management and therapy of systemic autoimmune myopathies (SAM). Main body The review of the literature was done in the search for the Medline (PubMed), Embase and Cochrane databases including studies published until June 2018. The Prisma was used for the systematic review and the articles were evaluated according to the levels of Oxford evidence. Ten recommendations were developed addressing the management and therapy of systemic autoimmune myopathies.Conclusions:
Robust data to guide the therapeutic process are scarce. Although not proven effective in controlled clinical trials, glucocorticoid represents first-line drugs in the treatment of SAM. Intravenous immunoglobulin is considered in induction for refractory cases of SAM or when immunosuppressive drugs are contra-indicated. Consideration should be given to the early introduction of immunosuppressive drugs. There is no specific period determined for the suspension of glucocorticoid and immunosuppressive drugs when individually evaluating patients with SAM. A key component for treatment in an early rehabilitation program is the inclusion of strengthbuilding and aerobic exercises, in addition to a rigorous evaluation of these activities for remission of disease and the education of the patient and his/her caregivers.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Autoimmune Diseases
/
Glucocorticoids
/
Immunosuppressive Agents
/
Muscular Diseases
Type of study:
Practice guideline
Limits:
Adult
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Adv Rheumatol
Journal subject:
Artrite
/
Reumatologia
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospitais de Reabilitação/BR
/
Hospital Geral de Fortaleza/BR
/
Universidade Federal de Pelotas/BR
/
Universidade de Sao Paulo/BR
/
Universidade do Estado do Rio de Janeiro/BR
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