Burden of rheumatoid arthritis on patients' work productivity and quality of life
Adv Rheumatol
;
59: 47, 2019. tab
Article
in English
| LILACS
| ID: biblio-1088596
ABSTRACT
Abstract Background:
To determine the burden of Rheumatoid Arthritis (RA) on patients' work productivity and health related quality of life (HRQoL), and examine the influence of several exposure variables; to analyze the progression of RA over 1 year and its impact on work productivity and HRQoL.Methods:
International multicenter prospective survey including patients in 18 centers in Argentina, Brazil, Colombia and Mexico with diagnosis of RA and aged between 21-55 years. The following standard questionnaires were completed at baseline and throughout a 1-year follow-up WPAIRA, WALS, WLQ-25, EQ-5D-3 L and SF-36. Clinical and demographic variables were also collected through interview.Results:
The study enrolled 290 patients on baseline visit. Overall mean scores at baseline visit were WPAIRA (presenteeism) = 29.5% (SD = 28.8%); WPAIRA (absenteeism) = 9.0% (SD = 23.2%); WPAIRA (absenteeism and presenteeism) = 8.6% (SD = 22.6%); WALS = 9.0 (SD = 6.1); WLQ-25 = 7.0% (SD = 5.1%); SF-36 Physical Scale = 39.1 (SD = 10.3) and Mental Scale = 45.4 (SD = 11.3); EQ-5D-3 L VAS = 69.8 (SD = 20.4) and EQ-5D-3 L index = 0.67 (SD = 0.23). Higher educational levels were associated with better results in WLQ-25, while previous orthopedic surgeries reduced absenteeism results of WPAIRA and work limitations in WLQ-25. Higher disease duration was associated with decreased HRQoL. Intensification of disease activity was associated with decreased work productivity and HRQoL, except in WLQ-25. In the longitudinal analysis, worsening in disease activity was associated with a decrease in both work productivity and HRQoL.Conclusions:
RA patients are dealing with workplace disabilities and limitations and loss in HRQoL, and multiple factors seems to be associated with this. Worsening of disease activity further decreased work productivity and HRQoL, stressing the importance of disease tight control.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Arthritis, Rheumatoid
/
Quality of Life
/
Efficiency
/
Work Performance
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Argentina
/
Brazil
/
Colombia
/
Mexico
Language:
English
Journal:
Adv Rheumatol
Journal subject:
Artrite
/
Reumatologia
Year:
2019
Type:
Article
Affiliation country:
Argentina
/
Brazil
/
Colombia
/
Mexico
Institution/Affiliation country:
AbbVie Farmacêutica Ltda/BR
/
CEIM Investigaciones Medicas/AR
/
Centro Integral de Reumatología/CO
/
Centro Paulista de Investigações Clínicas/BR
/
Centro de Investigaciones en Enfermedades Reumáticas/AR
/
Circaribe/CO
/
Desarrollos Biomédicos y Biotecnológicos/MX
/
Fundación Instituto de Reumatología Fernando Chalem/CO
/
Instituto Médico Especializado/AR
/
Morales Vargas Centro de Investigación/MX
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