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Benzbromarone in the treatment of gout
Azevedo, Valderilio Feijó; Kos, Igor Age; Vargas-Santos, Ana Beatriz; Pinheiro, Geraldo da Rocha Castelar; Paiva, Eduardo dos Santos.
  • Azevedo, Valderilio Feijó; Universidade Federal do Paraná. Curitiba. BR
  • Kos, Igor Age; Edumed Educação em Saúde. Curitiba. BR
  • Vargas-Santos, Ana Beatriz; Universidade Estadual do Rio de Janeiro. Rio de Janeiro. BR
  • Pinheiro, Geraldo da Rocha Castelar; Universidade Estadual do Rio de Janeiro. Rio de Janeiro. BR
  • Paiva, Eduardo dos Santos; Universidade Federal do Paraná. Curitiba. BR
Adv Rheumatol ; 59: 37, 2019.
Article in English | LILACS | ID: biblio-1088617
ABSTRACT
Abstract Background Benzbromarone is a uricosuric drug that has been used in the treatment of gout over the last 30 years. Due to its potent inhibition of the dominant apical (luminal) urate exchanger in the human proximal tubule URAT1, it reduces the urate reabsorption, diminishing serum urate levels and therefore preventing gout flares. Main body of the abstract Through several clinical trials, Benzbromarone has been proved effective and safe, inclusive in patients with chronic kidney disease and as combination therapy with allopurinol. Due to hepatotoxicity reports, it was withdrawn from the European market by the manufacturer, however many authors have questioned the product's withdrawal due to a lack of clinical evidence in order to support its hepatotoxicity. Benzbromarone is still available in several European countries, New Zealand, Brazil and several other countries. Despite the product's marketing over more than 20 years after the first hepatotoxicity reports, we have found only five reports in our literature search, and no prospective or retrospective study correlating hepatotoxicity with benzbromarone use. Short conclusion Benzbromarone is a safe and effective molecule for the treatment of gout. However, due to in vitro and in vivo data related to hepatotoxicity, it is prudent to prescribe it with some caution, especially for patients with an already known liver condition.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Benzbromarone / Gout Type of study: Observational study / Risk factors Limits: Humans Language: English Journal: Adv Rheumatol Journal subject: Artrite / Reumatologia Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Edumed Educação em Saúde/BR / Universidade Estadual do Rio de Janeiro/BR / Universidade Federal do Paraná/BR

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Full text: Available Index: LILACS (Americas) Main subject: Benzbromarone / Gout Type of study: Observational study / Risk factors Limits: Humans Language: English Journal: Adv Rheumatol Journal subject: Artrite / Reumatologia Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Edumed Educação em Saúde/BR / Universidade Estadual do Rio de Janeiro/BR / Universidade Federal do Paraná/BR