Evaluation of the association between KIR polymorphisms and systemic sclerosis: a meta-analysis
Adv Rheumatol
;
60: 08, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1088648
ABSTRACT
Abstract Background:
The results of investigations on the association between killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and the risk of systemic sclerosis (SSc) are inconsistent. To comprehensively evaluate the influence of KIR polymorphisms on the risk of SSc, this meta-analysis was performed.Methods:
A systematic literature search was performed in electronic databases including Scopus and PubMed/ MEDLINE to find all available studies involving KIR gene family polymorphisms and SSc risk prior to July 2019. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were measured to detect associations between KIR gene family polymorphisms and SSc risk.Results:
Five articles, comprising 571 patients and 796 healthy participants, evaluating the KIR gene family polymorphisms were included in the final meta-analysis according to the inclusion and exclusion criteria, and 16 KIR genes were assessed. None of the KIR genes were significantly associated with the risk of SSc.Conclusions:
The current meta-analysis provides evidence that KIR genes might not be potential risk factors for SSc risk.(AU)
Full text:
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Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Scleroderma, Systemic
Type of study:
Etiology study
/
Evaluation studies
/
Risk factors
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Adv Rheumatol
Journal subject:
Artrite
/
Reumatologia
Year:
2020
Type:
Article
Affiliation country:
Brazil
/
Iran
Institution/Affiliation country:
Kermanshah University of Medical Sciences/IR
/
Tehran University of Medical Sciences/IR
/
Universidade Federal do Rio Grande do Sul/BR
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