Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review
An. bras. dermatol
;
95(1): 63-66, Jan.-Feb. 2020. graf
Article
in English
| LILACS
| ID: biblio-1088728
ABSTRACT
Abstract Topical use of immune response modifiers, such as imiquimod, has increased in dermatology. Although its topical use is well tolerated, it may be associated with exacerbations of generalized cutaneous inflammatory diseases, possibly through the systemic circulation of pro-inflammatory cytokines. This report describes a case of development of pityriasis rubra pilaris, a rare erythematous-papulosquamous dermatosis, in a woman aged 60 years during treatment with imiquimod 5% cream for actinic keratosis. It evolved with erythrodermic conditions and palmoplantar keratoderma, presenting progressive clinical resolution after the introduction of methotrexate. The authors emphasize the importance of recognizing possible systemic reactions associated with the topical use of imiquimod.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pityriasis Rubra Pilaris
/
Keratosis, Actinic
/
Imiquimod
/
Antineoplastic Agents
Type of study:
Risk factors
Limits:
Female
/
Humans
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Dermoclínica/BR
/
Universidade Estadual de Campinas/BR
Similar
MEDLINE
...
LILACS
LIS