Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
Arch. endocrinol. metab. (Online)
;
64(1): 89-95, Jan.-Feb. 2020. graf
Article
in English
| LILACS
| ID: biblio-1088770
ABSTRACT
ABSTRACT Clinical and subclinical hypothyroidism are the most common hormonal dysfunctions during pregnancy. Insufficient maternal thyroid hormones (THs) in the early stages of pregnancy can lead to severe impairments in the development of the central nervous system because THs are critical to central nervous system development. In the fetus and after birth, THs participate in neurogenic processes, cell differentiation, neuronal activation, axonal growth, dendritic arborization, synaptogenesis and myelination. Although treatment is simple and effective, approximately 30% of pregnant women in Brazil with access to prenatal care have their first consultation after the first trimester of pregnancy, and any delay in diagnosis and resulting treatment delay may lead to cognitive impairment in children. This review summarizes the effects of clinical and subclinical hypothyroidism on fetal neurodevelopment, behavior and cognition in humans and rodents. Arch Endocrinol Metab. 2020;64(1)89-95
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pregnancy Complications
/
Brain
/
Cognitive Dysfunction
/
Hypothyroidism
/
Maternal-Fetal Exchange
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Arch. endocrinol. metab. (Online)
Journal subject:
Endocrinology
/
Metabolism
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Presbiteriana Mackenzie/BR
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