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Evaluation of Electrocardiographic Ventricular Depolarization and Repolarization Variables in Type 1 Diabetes Mellitus / Avaliação de Variáveis Eletrocardiográficas de Despolarização e Repolarização Ventricular em Diabetes Mellitus Tipo 1
Inanır, Mehmet; Gunes, Yilmaz; Sincer, Isa; Erdal, Emrah.
  • Inanır, Mehmet; Abant Izzet Baysal University Hospital. Bolu. TR
  • Gunes, Yilmaz; Abant Izzet Baysal University Hospital. Bolu. TR
  • Sincer, Isa; Abant Izzet Baysal University Hospital. Bolu. TR
  • Erdal, Emrah; Abant Izzet Baysal University Hospital. Bolu. TR
Arq. bras. cardiol ; 114(2): 275-280, Feb. 2020. tab
Article in English | LILACS | ID: biblio-1088873
ABSTRACT
Abstract

Background:

The risk of cardiovascular events and sudden death increases with type 1 diabetes mellitus (T1DM).

Objective:

To evaluate electrocardiographic markers of arrhythmias in T1DM patients.

Methods:

Electrocardiographic parameters reflecting ventricular depolarization and repolarization, namely, QT, QTc, QTd, QTdc, Tp-e, JT, and JTc intervals and Tp-e/QT and Tp-e/QTc ratios, of 46 patients diagnosed with T1DM were retrospectively analyzed and compared with 46 healthy age-, sex-, and body mass-matched controls. Correlations between T1DM duration, hemoglobin A1c (HbA1c), and ventricular repolarization variables were analyzed. P values lower than 0.05 were considered statistically significant.

Results:

Diabetes duration was 16.6 ± 7.1 years, and HbA1c was 10.81% ± 3.27% in the T1DM group. In comparison with the control group, heart rate, QTc, QTd, QTdc, Tp-e and JTc intervals, Tp-e/QT ratio (p < 0.001), and Tp-e/QTc ratio (p = 0.007) were significantly higher in T1DM patients. T1DM duration and HbA1c levels were significantly correlated with QTc, QTd, QTdc, Tp-e, and JTc intervals and Tp-e/QT and Tp-e/QTc ratios.

Conclusions:

In T1DM patients, potential electrocardiographic repolarization predictors were significantly increased in correlation with disease duration and HbA1c levels. These findings may contribute to the understanding of sudden cardiac death in patients with T1DM.
RESUMO
Resumo Fundamento O risco de eventos cardiovasculares e morte súbita aumenta com diabetes mellitus tipo 1 (DM1).

Objetivo:

Avaliar alguns marcadores eletrocardiográficos de arritmias em pacientes com DM1.

Métodos:

Parâmetros eletrocardiográficos que refletem despolarização e repolarização ventricular, a saber, os intervalos QT, QTc, QTd, QTdc, Tp-e, JT e JTc e as relações Tp-e/QT e Tp-e/QTc, de 46 pacientes diagnosticados com DM1 foram retrospectivamente analisados e comparados com 46 controles saudáveis, pareados por idade, sexo e massa corporal. As correlações entre duração de DM1, HbA1c e variáveis de repolarização ventricular foram analisadas. Foram considerados estatisticamente significativos os valores de p inferiores a 0,05.

Resultados:

A duração de diabetes foi de 16,6 ± 7,1 anos, e HbA1c foi 10,81% ± 3,27% no grupo DM1. Em comparação com o grupo controle, a frequência cardíaca, os intervalos QTc, QTd, QTdc, Tp-e e JTc, a relação Tp-e/QT (p < 0,001) e a relação Tp-e/QTc (p = 0,007) foram significativamente mais altos em pacientes com DM1. A duração de DM1 e os níveis de HbA1c foram significativamente correlacionados com os intervalos QTc, QTd, QTdc, Tp-e e JTc e com as relações Tp-e/QT e Tp-e/QTc.

Conclusões:

Em pacientes com DM1, potenciais preditores eletrocardiográficos de repolarização foram significativamente aumentados em correlação com a duração da doença e com os níveis de HbA1c. Estes achados podem contribuir à compreensão da morte súbita cardíaca em pacientes com DM1.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Arrhythmias, Cardiac / Diabetes Mellitus, Type 1 Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Abant Izzet Baysal University Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Arrhythmias, Cardiac / Diabetes Mellitus, Type 1 Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Abant Izzet Baysal University Hospital/TR