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Clinical studies using stem cells for treatment of retinal diseases: state of the art / Estudos clínicos com uso de células-tronco para tratamento de doenças da retina: estado da arte
Cotrim, Carina Costa; Jorge, Rodrigo; Oliveira, Maria Carolina de; Pieroni, Fabiano; Messias, André M. Vieira; Siqueira, Rubens Camargo.
  • Cotrim, Carina Costa; Universidade de São Paulo. Faculty of Medicine of Ribeirão Preto. Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery. Ribeirão Preto. BR
  • Jorge, Rodrigo; Universidade de São Paulo. Faculty of Medicine of Ribeirão Preto. Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery. Ribeirão Preto. BR
  • Oliveira, Maria Carolina de; Universidade de São Paulo. Faculty of Medicine of Ribeirão Preto. Department of Internal Medicine. Ribeirão Preto. BR
  • Pieroni, Fabiano; Universidade de São Paulo. Faculty of Medicine of Ribeirão Preto. Department of Internal Medicine. Ribeirão Preto. BR
  • Messias, André M. Vieira; Universidade de São Paulo. Faculty of Medicine of Ribeirão Preto. Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery. Ribeirão Preto. BR
  • Siqueira, Rubens Camargo; Universidade de São Paulo. Faculty of Medicine of Ribeirão Preto. Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery. Ribeirão Preto. BR
Arq. bras. oftalmol ; 83(2): 160-167, Mar.-Apr. 2020. tab, graf
Article in English | LILACS | ID: biblio-1088965
ABSTRACT
ABSTRACT Degenerative retinal diseases such as retinitis pigmentosa, Stargardt's macular dystrophy, and age-related macular degeneration are characterized by irreversible loss of vision due to direct or indirect photoreceptor damage. No effective treatments exist, but stem cell studies have shown promising results. Our aim with this review was to describe the types of stem cells that are under study, their effects, and the main clinical trials involving them.
RESUMO
RESUMO As doenças degenerativas da retina, como retinose pigmentar, distrofia macular de Stargardt e degeneração macular relaciona à idade, são caracterizadas por perda irre versível da visão devido a danos diretos ou indiretos aos fotorreceptores. Não existem tratamentos eficazes, porém os estudos com células-tronco mostraram resultados promissores. Nosso objetivo com esta revisão foi descrever os tipos de células-tronco em estudo, seus efeitos e os principais ensaios clínicos que as envolvem.
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Full text: Available Index: LILACS (Americas) Main subject: Retinal Degeneration / Pluripotent Stem Cells / Stem Cell Transplantation Limits: Humans Language: English Journal: Arq. bras. oftalmol Journal subject: Ophthalmology Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Retinal Degeneration / Pluripotent Stem Cells / Stem Cell Transplantation Limits: Humans Language: English Journal: Arq. bras. oftalmol Journal subject: Ophthalmology Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR