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Optical coherence tomography angiography findings in patients with branch retinal vein occlusion treated with Anti-VEGF / Achados de angiografia por tomografia de coerência óptica em pacientes com oclusão de ramo da veia retiniana tratada com anti-VEGF
Ciloglu, Emine; Dogan, Neşe Çetin.
  • Ciloglu, Emine; Adana City Training and Research Hospital. Department of Ophthalmology. Adana. TR
  • Dogan, Neşe Çetin; Adana City Training and Research Hospital. Department of Ophthalmology. Adana. TR
Arq. bras. oftalmol ; 83(2): 120-126, Mar.-Apr. 2020. tab, graf
Article in English | LILACS | ID: biblio-1088977
ABSTRACT
ABSTRACT

Purpose:

To investigate retinal microvasculature changes in patients treated with anti-VEGF for macular edema secondary to branch retinal vein occlusion.

Methods:

We examined 38 eyes of 19 patients for the study. We measured superficial and deep capillary plexus vessel densities (%), foveal avascular zone areas (mm2), and central macular thicknesses.

Results:

Parafoveal superficial and deep capillary plexus values were significantly lower in eyes with branch retinal vein occlusion than in fellow eyes (p<0.001). We found a significant increase in parafoveal deep capillary plexus values after the anti-VEGF treatment (p=0.032). The mean foveal avascular zone was larger in eyes with branch retinal vein occlusion than in control eyes (p<0.001). The mean central macular thickness was significantly higher in eyes with branch retinal vein occlusion than in controls, and we observed a significant decrease in central macular thickness after anti-VEGF treatment (<0.001). In addition, the cystic structures in the deep capillary plexus regressed.

Conclusion:

Optical coherence tomography angiography enables qualitative and quantitative evaluations during follow-up of patients treated for branch retinal vein occlusion.
RESUMO
RESUMO

Objetivo:

Investigar as alterações na microvascu latura da retina em pacientes tratados com anti-VEGF para ede ma macular secundário à oclusão de ramo da veia retiniana.

Métodos:

Foram examinados 38 olhos de 19 pacientes para o estudo. Medimos as densidades dos vasos do plexo capilar superficial e profunda (%), áreas da zona avascular foveal (mm2) e espessura macular central.

Resultados:

Os valores do plexo capilar superficial e profundo parafoveal foram significativamente menores nos olhos com oclusão de ramo da veia retiniana do que nos outros olhos (p<0,001). Encontramos um aumento significativo nos valores de plexo capilar profundo parafoveal após o tratamento com anti-VEGF (p=0,032). A zona avascular foveal média foi maior nos olhos com oclusão de ramo da veia retiniana do que nos olhos controle (p<0,001). A espessura macular central média foi significativamente maior nos olhos com oclusão de ramo da veia retiniana do que nos controles, e observamos uma diminuição significativa na espessura macular central após o tratamento com anti-VEGF (< 0,001). Além disso, as estruturas císticas no plexo capilar profundo regrediram.

Conclusão:

A angiotomografia de coerência óptica permite avaliações qualitativas e quantitativas durante o acompanhamento de pacientes tratados por oclusão de ramo da veia retiniana.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Retinal Vein Occlusion / Fluorescein Angiography / Macular Edema / Angiogenesis Inhibitors / Vascular Endothelial Growth Factor A / Tomography, Optical Coherence Type of study: Diagnostic study / Etiology study / Observational study / Qualitative research / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Arq. bras. oftalmol Journal subject: Ophthalmology Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Adana City Training and Research Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Retinal Vein Occlusion / Fluorescein Angiography / Macular Edema / Angiogenesis Inhibitors / Vascular Endothelial Growth Factor A / Tomography, Optical Coherence Type of study: Diagnostic study / Etiology study / Observational study / Qualitative research / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Arq. bras. oftalmol Journal subject: Ophthalmology Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Adana City Training and Research Hospital/TR