Your browser doesn't support javascript.
loading
Complement factor H levels are decreased and correlated with serum C-reactive protein in late-onset Alzheimer's disease / Os níveis de fator H do complemento estão diminuídos e correlacionados com a proteína C-reativa sérica na doença de Alzheimer de início tardio
Lu, Guo; Liu, Weihong; Huang, Xinying; Zhao, Yanxin.
  • Lu, Guo; Dezhou People's Hospital. Department of Neurology. Dezhou. CN
  • Liu, Weihong; Dezhou People's Hospital. Department of Medicine Nuclear. Dezhou. CN
  • Huang, Xinying; Dezhou People's Hospital. Department of Neurology. Dezhou. CN
  • Zhao, Yanxin; Jinan Central Hospital. Department of Neurology. Jinan. CN
Arq. neuropsiquiatr ; 78(2): 76-80, Feb. 2020. tab, graf
Article in English | LILACS | ID: biblio-1088993
ABSTRACT
Abstract Alzheimer's disease (AD) is the most common cause of dementia. Despite numerous studies on the subject, the pathologies for AD are still unclear and there is still no ideal biomarker for diagnosis. The present study aimed to investigate clinical significance of human complement factor H (CFH) in patients with late-onset AD.

Methods:

The present prospective study included 187 late-onset AD patients who went to our hospital from January 2015 to December 2017. One hundred patients with mild cognitive impairment (MCI) and 80 healthy individuals who were age and gender matched to AD patients were enrolled as controls. Demographic data such as age, gender, and education duration were recorded. Blood samples were collected and serum levels of C-reactive protein (CRP), CFH, and brain-derived neurotrophic factor (BDNF) were determined by Enzyme-linked immunosorbent assay (ELISA). The mini-mental state examination (MMSE) score was measured for all patients.

Results:

No significant difference was found in age, gender, and education duration for all participants. The MMSE scores showed AD patients had lower MMES scores than the other two groups. All factors of CFH, CRP, and BDNF were dramatically decreased in AD patients compared with the MCI and the ealthy control. Levels of CFH were found to be positively correlated with levels of CRP; however, no significant correlation was found between CFH and BDNF, nor CFH and MMSE.

Conclusion:

CFH was decreased in late-onset AD patients, and serum levels of CFH was correlated with serum levels of CRP, but not MMSE and BDNF. These results may provide more clinical evidences for the role of CFH in AD patients.
RESUMO
Resumo A doença de Alzheimer (DA) é a causa mais comum de demência. Apesar de inúmeros estudos sobre DA, suas patologias ainda não são claras e ainda não existe um biomarcador ideal para o diagnóstico da condição. O presente estudo teve como objetivo investigar a significância clínica do fator H do complemento humano (CFH) em pacientes com DA de início tardio.

Métodos:

O presente estudo prospectivo incluiu um total de 187 pacientes com DA de início tardio que foram ao nosso hospital entre janeiro de 2015 e dezembro de 2017. Cem pacientes com comprometimento cognitivo leve (CCL) e 80 indivíduos saudáveis com idade e sexo pareados com pacientes com DA foram incluídos como controle. Dados demográficos como idade, sexo e duração da educação foram registrados. As amostras de sangue foram coletadas e os níveis séricos de proteína C-reativa (PCR), CFH e fator neurotrófico derivado do cérebro (BDNF) foram determinados pelo ensaio imunoabsorvente ligado à enzima (ELISA). O escore do miniexame do estado mental (MEEM) foi medido para todos os pacientes.

Resultados:

Não foram encontradas diferenças significativas em idade, sexo e duração da educação para todos os participantes. Pacientes com DA tinham os menores escores de MEEM em relação aos outros dois grupos. Todos os fatores de CFH, PCR e BDNF diminuíram drasticamente em pacientes com DA em comparação com o CCL e o controle saudável. Os níveis de CFH mostraram correlação positiva com os níveis de PCR; no entanto, não foi encontrada correlação significativa entre CFH e BDNF, nem CFH e MEEM.

Conclusão:

A CFH diminuiu nos pacientes com DA de início tardio e os níveis séricos de CFH foram correlacionados com os níveis séricos de PCR, mas não o MEEM e o BDNF. Esses resultados podem fornecer mais evidências clínicas do papel da CFH em pacientes com DA.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: C-Reactive Protein / Complement Factor H / Alzheimer Disease Type of study: Observational study Limits: Humans Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2020 Type: Article Affiliation country: China Institution/Affiliation country: Dezhou People's Hospital/CN / Jinan Central Hospital/CN

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: C-Reactive Protein / Complement Factor H / Alzheimer Disease Type of study: Observational study Limits: Humans Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2020 Type: Article Affiliation country: China Institution/Affiliation country: Dezhou People's Hospital/CN / Jinan Central Hospital/CN