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Preparation of extemporaneous oral liquid in the hospital pharmacy
Galenic Development Laboratory (LADEG)Silva, Márcio Robert Mattos da; Galenic Development Laboratory (LADEG)Dysars, Letícia Pereira; Galenic Development Laboratory (LADEG)Santos, Elisabete Pereira dos; Galenic Development Laboratory (LADEG)Ricci Júnior, Eduardo.
  • Galenic Development Laboratory (LADEG)Silva, Márcio Robert Mattos da; Federal University of Rio de Janeiro. Department of Medicine. Galenic Development Laboratory (LADEG)Silva, Márcio Robert Mattos da. Rio de Janeiro. BR
  • Galenic Development Laboratory (LADEG)Dysars, Letícia Pereira; Federal University of Rio de Janeiro. Department of Medicine. Galenic Development Laboratory (LADEG)Dysars, Letícia Pereira. Rio de Janeiro. BR
  • Galenic Development Laboratory (LADEG)Santos, Elisabete Pereira dos; Federal University of Rio de Janeiro. Department of Medicine. Galenic Development Laboratory (LADEG)Santos, Elisabete Pereira dos. Rio de Janeiro. BR
  • Galenic Development Laboratory (LADEG)Ricci Júnior, Eduardo; Federal University of Rio de Janeiro. Department of Medicine. Galenic Development Laboratory (LADEG)Ricci Júnior, Eduardo. Rio de Janeiro. BR
Braz. J. Pharm. Sci. (Online) ; 56: e18358, 2020. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1089216
ABSTRACT
At the hospital, the pharmacist is constantly challenged to prepare extemporaneous solutions from tablets, capsules or drug powder for patients unable to swallow, such as pediatric, elderly and patients that use nasoenteric and nasogastric tubes. The preparation of extemporaneous solutions from capsules, tablets and drug powder requires stability studies analysis. This article is a bibliographic review of preparation of extemporaneous oral liquid from solid oral dosage forms used in clinical practice. The selected articles contain all the information regarding manipulation techniques, pharmaceutical excipients, packaging, storage conditions and results of stability studies above 90% performed by HPLC analysis. In addition, a situational analysis of the strategies for the preparation of the extemporaneous solution was described to help the manipulator in the decision. The preparation of extemporaneous solution from solid oral dosage forms is based on information from official compendium or scientific literature, to ensure safe and effective manipulated medicine.


Full text: Available Index: LILACS (Americas) Type of study: Prognostic study Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Rio de Janeiro/BR

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Full text: Available Index: LILACS (Americas) Type of study: Prognostic study Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Rio de Janeiro/BR