PAK6: a potential anti-cancer target
Braz. J. Pharm. Sci. (Online)
;
56: e18315, 2020. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1089222
ABSTRACT
p21-activated kinase 6 (PAK6) is a member of the PAK family of serine/threonine kinases that are known effectors of Rho GTPases Cdc42 and Rac. PAKs regulate a large number of complex cellular mechanisms, including cell motility, morphology, and tumor development. PAK6, initially cloned as an interacting partner of the androgen receptor (AR), is associated with an array of cellular processes implicated in tumor progression. However, the full biological implications of PAK6 activity during cancer remain poorly understood. In this review, we assess our current understanding of the physiological roles of classical PAK6 functionality in mammals, in addition to its emerging role in tumorigenesis.
Full text:
Available
Index:
LILACS (Americas)
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2020
Type:
Article
/
Project document
Affiliation country:
China
Institution/Affiliation country:
Xuzhou Medical University/CN
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