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The APOB rs693 polymorphism impacts the lipid profile of Brazilian older adults
Alves, E S; Henriques, A D; Tonet-Furioso, A C; Paula, R S; Gomes, L O; Moraes, C F; Nóbrega, O T.
  • Alves, E S; Universidade de Brasília. Faculdade de Ciências da Saúde. Programa de Pós-Graduação em Ciências da Saúde. Brasília. BR
  • Henriques, A D; Universidade de Brasília. Faculdade de Ciências da Saúde. Programa de Pós-Graduação em Ciências da Saúde. Brasília. BR
  • Tonet-Furioso, A C; Universidade de Brasília. Faculdade de Medicina. Programa de Pós-Graduação em Ciências Médicas. Brasília. BR
  • Paula, R S; Universidade de Brasília. Faculdade de Ciências da Saúde. Programa de Pós-Graduação em Ciências da Saúde. Brasília. BR
  • Gomes, L O; Universidade Católica de Brasília. Escola de Saúde e Medicina. Programa de Pós-Graduação em Gerontologia. Brasília. BR
  • Moraes, C F; Universidade de Brasília. Faculdade de Medicina. Programa de Pós-Graduação em Ciências Médicas. Brasília. BR
  • Nóbrega, O T; Universidade de Brasília. Faculdade de Ciências da Saúde. Programa de Pós-Graduação em Ciências da Saúde. Brasília. BR
Braz. j. med. biol. res ; 53(3): e9102, 2020. tab, graf
Article in English | LILACS | ID: biblio-1089346
ABSTRACT
The apolipoprotein B (APOB) gene contains several polymorphic sites described as risk modifiers for cardiovascular events. The objective of this study was to verify the association of the classic APOB Xba I polymorphism (rs693) with atherosclerotic risk factors in a segment of the Brazilian elderly population considering their usual dietary intake. Clinical and biochemical characteristics as well as total caloric and fat intake data were determined from 644 elderly individuals. Polymorphism analysis was performed by conventional polymerase chain reaction followed by enzyme restriction. Statistical analyses compared measures and proportions according to different APOB genotypic combinations. Statistically significant association was found between Xba I polymorphism and serum LDL, total cholesterol, and total lipid levels, with important elevations among T homozygotes compared to the other genotypes. There was homogeneity in all other parameters analyzed (including intake pattern), with a tendency for reduced levels of circulating apolipoprotein B among TT individuals. Our results pointed out that genetic variation in APOB affected the lipemic profile of elderly individuals in a context not biased by diet, generating a pattern suggestive of secretory disorder of lipoprotein particles, with possible implication in atherosclerotic risk.
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Full text: Available Index: LILACS (Americas) Main subject: Apolipoproteins B / Polymorphism, Genetic / Genetic Predisposition to Disease / Atherosclerosis / Feeding Behavior / Lipids Type of study: Etiology study / Prognostic study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Católica de Brasília/BR / Universidade de Brasília/BR

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Full text: Available Index: LILACS (Americas) Main subject: Apolipoproteins B / Polymorphism, Genetic / Genetic Predisposition to Disease / Atherosclerosis / Feeding Behavior / Lipids Type of study: Etiology study / Prognostic study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Católica de Brasília/BR / Universidade de Brasília/BR