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The Difference in Thyroid Stimulating Hormone Levels between Differentiated Carcinoma and Benign Enlargement
Rianto, Bambang Udji Djoko; Wibowo, Anton Sony; Herdini, Camelia.
  • Rianto, Bambang Udji Djoko; Universitas Gadjah Mada. Faculty of Medicine. Ear Nose Throat Head and Head Neck Surgery Department. Yogyakarta. ID
  • Wibowo, Anton Sony; Universitas Gadjah Mada. Faculty of Medicine. Ear Nose Throat Head and Head Neck Surgery Department. Yogyakarta. ID
  • Herdini, Camelia; Universitas Gadjah Mada. Faculty of Medicine. Ear Nose Throat Head and Head Neck Surgery Department. Yogyakarta. ID
Int. arch. otorhinolaryngol. (Impr.) ; 24(1): 73-79, Jan.-Mar. 2020. tab
Article in English | LILACS | ID: biblio-1090558
ABSTRACT
Abstract Introduction Papillary and follicular thyroid carcinoma are common head and neck cancers. This cancer expresses a thyroid stimulating hormone (TSH) receptor that plays a role as a cancer stimulant substance. This hormone has a diagnostic value in the management of thyroid carcinoma. Objective The present study aimed to determine the difference in TSH levels between differentiated thyroid carcinoma and benign thyroid enlargement. Methods The present research design was a case-control study. The subjects were patients with thyroid enlargement who underwent thyroidectomies at the Dr. Sardjito General Hospital, Yogyakarta, Indonesia. Thyroid stimulating hormone levels were mea- sured before the thyroidectomies. The inclusion criteria for the case group were 1) differentiated thyroid carcinoma, and 2) complete data; while the inclusion criteria for the control group were 1) benign thyroid enlargement, and 2) complete data. The exclusion criteria for both groups were 1) patients suffering from thyroid hormone disorders requiring therapy before thyroidectomy surgery, 2) patients receiving thyroid suppression therapy before the thyroidectomy was performed, and 3) patients suffering from severe chronic diseases such as renal insufficiency, and severe liver disease. Results There were 40 post-thyroidectomy case group patients and 40 post-thyroidect- omy control group patients. There were statistically significant differences in TSH levels between the groups with differentiated thyroid carcinoma and benign thyroid enlargement (p = 0.001; odds ratio [OR] = 8.42; 95% confidence interval [CI] 3.19-36.50). Conclusion Based on these results, it can be concluded that there were significant differences in TSH levels between the groups with differentiated thyroid carcinoma and benign thyroid enlargement.
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Full text: Available Index: LILACS (Americas) Main subject: Thyroid Neoplasms / Thyrotropin / Adenocarcinoma, Follicular / Thyroid Cancer, Papillary Type of study: Diagnostic study / Observational study Limits: Adolescent / Adult / Aged / Female / Humans / Male Language: English Journal: Int. arch. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2020 Type: Article Affiliation country: Indonesia Institution/Affiliation country: Universitas Gadjah Mada/ID

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Full text: Available Index: LILACS (Americas) Main subject: Thyroid Neoplasms / Thyrotropin / Adenocarcinoma, Follicular / Thyroid Cancer, Papillary Type of study: Diagnostic study / Observational study Limits: Adolescent / Adult / Aged / Female / Humans / Male Language: English Journal: Int. arch. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2020 Type: Article Affiliation country: Indonesia Institution/Affiliation country: Universitas Gadjah Mada/ID