Expert Opinions on Managing Fertility and Pregnancy in Patients With Mucopolysaccharidosis
J. inborn errors metab. screen
;
4: e160029, 2016. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1090890
ABSTRACT
Abstract The mucopolysaccharidosis (MPS) disorders are rare genetic diseases caused by deficiencies in lysosomal enzymes involved in the degradation of glycosaminoglycans, leading to pulmonary, cardiac and neurological dysfunctions, skeletal anomalies, impaired vision, and/or hearing and shortened life spans. Whereas in the past, few individuals with MPS reached adulthood, better diagnosis, multidisciplinary care, and new therapies have led to an increasing number of adult patients with MPS. Therefore, fertility and pregnancy questions in this patient population are becoming more important. Management of fertility issues and pregnancy in patients with MPS is challenging due to the lack of documented cases and a dearth in the literature on this topic. This review presents multidisciplinary expert opinions on managing fertility and pregnancy based on case studies and clinical experience presented at a meeting of MPS specialists held in Berlin, Germany, in April 2015. An overview of the existing literature on this subject is also included.
Full text:
Available
Index:
LILACS (Americas)
Language:
English
Journal:
J. inborn errors metab. screen
Journal subject:
Medicina Cl¡nica
/
Patologia
Year:
2016
Type:
Article
Affiliation country:
Austria
/
Canada
/
France
/
Germany
/
United States
/
United kingdom
Institution/Affiliation country:
Belfast City Hospital/GB
/
BioMarin Europe Limited/GB
/
BioMarin Pharmaceutical Inc/US
/
Birmingham Women's NHS Foundation Trust/GB
/
Central Manchester University Hospitals/GB
/
Charité Universitätsmedizin Berlin/DE
/
Hôpital Femme Mère Enfants/FR
/
Lurie Children's Hospital/US
/
Medical University of Vienna/AT
/
Montreal Children's Hospital/CA
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