Newborn Screening for Phenylketonuria: Latin American Consensus Guidelines
J. inborn errors metab. screen
;
4: e160034, 2016.
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1090905
ABSTRACT
Abstract Newborn screening (NBS) for phenylketonuria in Latin America gave its first step in an organized way 3 decades ago when the first national NBS program was implemented in Cuba. From then onward, it experienced a slow but continuous growing, being currently possible to find from countries where no NBS activity is known to several countries with consolidated NBS programs. This complex scenario gave rise to a great diversity in the criteria used for sample collection, selection of analytical methods, and definition of cutoff values. Considering this context, a consensus meeting was held in order to unify such criteria, focusing the discussion in the following aspects—recommended blood specimens and sample collection time; influence of early discharge, fasting, parenteral nutrition, blood transfusions, extracorporeal life support, and antibiotics; main causes of transient hyperphenylalaninemias; required characteristics for methods used in phenylalanine measurement; and finally, criteria to define the more appropriate cutoff values.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Diagnostic study
/
Practice guideline
/
Screening study
Language:
English
Journal:
J. inborn errors metab. screen
Journal subject:
Medicina Cl¡nica
/
Patologia
Year:
2016
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Fundación Bioquímica Argentina/AR
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