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Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation / Exposição pré-natal a mofo está associada ao desenvolvimento de dermatite atópicaem neonatos por reação alérgica
Lee, Eun; Choi, Kil Yong; Kang, Mi-Jin; Lee, So-Yeon; Yoon, Jisun; Cho, Hyun-Ju; Jung, Sungsu; Lee, Si Hyeon; Suh, Dong In; Shin, Youn Ho; Kim, Kyung Won; Ahn, Kangmo; Hong, Soo-Jong.
  • Lee, Eun; Chonnam National University Hospital. Chonnam National University Medical School. Department of Pediatrics. Gwangju. KR
  • Choi, Kil Yong; Pusan National University. Department of Environmental Engineering. Busan. KR
  • Kang, Mi-Jin; University of Ulsan College of Medicine. Asan Institute for Life Sciences. Seoul. KR
  • Lee, So-Yeon; University of Ulsan College of Medicine. Childhood Asthma and Atopy Center. Department of Pediatrics. Seoul. KR
  • Yoon, Jisun; Mediplex Sejong Hospital. Department of Pediatrics. Incheon. KR
  • Cho, Hyun-Ju; International St. Mary's Hospital. Catholic Kwandong University. Department of Pediatrics. Incheon. KR
  • Jung, Sungsu; University of Ulsan College of Medicine. Childhood Asthma and Atopy Center. Department of Pediatrics. Seoul. KR
  • Lee, Si Hyeon; University of Ulsan College of Medicine. Asan Institute for Life Sciences. Seoul. KR
  • Suh, Dong In; Seoul National University College of Medicine. Department of Pediatrics. Seoul. KR
  • Shin, Youn Ho; CHA Medical Center. CHA University School of Medicine. Department of Pediatrics. Seoul. KR
  • Kim, Kyung Won; Yonsei University. College of Medicine. Severance Children's Hospital. Seoul. KR
  • Ahn, Kangmo; Sungkyunkwan University. School of Medicine. Samsung Medical Center. Seoul. KR
  • Hong, Soo-Jong; University of Ulsan College of Medicine. Childhood Asthma and Atopy Center. Department of Pediatrics. Seoul. KR
J. pediatr. (Rio J.) ; 96(1): 125-131, Jan.-Feb. 2020. tab, graf
Article in English | LILACS | ID: biblio-1090999
ABSTRACT
Abstract Objective Mold exposure in early life may be associated with development of atopic dermatitis; however, studies of this link are inconclusive and evidence for the underlying mechanism(s) is lacking. This study identified the association between the time of mold exposure and development of atopic dermatitis and investigated the underlying mechanisms. Method The association between atopic dermatitis and mold exposure was examined in the Cohort for Childhood Origin of Asthma and Allergic Diseases birth cohort study (n = 1446). Atopic dermatitis was diagnosed at 1 year of age by pediatric allergists. Exposure to mold was assessed by questionnaire. The Illumina MiSeq platform was used to examine the environmental mycobiome in 20 randomly selected healthy infants and 20 infants with atopic dermatitis at 36 weeks of gestation. Results Prenatal, but not postnatal, mold exposure was significantly associated with atopic dermatitis (adjusted odds ratio, 1.36; 95% confidence interval, 1.01-1.83). Levels of total serum IgE at 1 year of age were higher in infants with atopic dermatitis exposed to mold during pregnancy than in healthy infants not exposed to mold during pregnancy (p = 0.021). The relative abundance of uncultured Ascomycota was higher in infants with atopic dermatitis than in healthy infants. The relative abundance of uncultured Ascomycota correlated with total serum IgE levels at 1 year of age (r = 0.613, p < 0.001). Conclusion Indoor mold exposure during the fetal period is associated with development of atopic dermatitis via IgE-mediated allergic inflammation. Avoidance of mold exposure during this critical period might prevent the development of atopic dermatitis.
RESUMO
Resumo Objetivo A exposição ao mofo no início da vida pode estar associada ao desenvolvimento de dermatite atópica; contudo, os estudos sobre esse vínculo são inconclusivos e faltam evidências dos mecanismos subjacentes. Identificamos a associação entre o momento da exposição ao mofo e o desenvolvimento de dermatite atópica e investigamos os mecanismos subjacentes. Método A associação entre dermatite atópica e exposição a mofo foi examinada em um estudo de coorte de nascimento da Origem da Asma e de Doenças Alérgicas em Crianças (COCOA) (n = 1446). A dermatite atópica foi diagnosticada em pacientes com um ano de vida por pediatras alergistas. A exposição ao mofo foi avaliada por um questionário. A plataforma Illumina MiSeq foi utilizada para examinar o microbioma ambiental em 20 neonatos saudáveis escolhidos aleatoriamente e 20 com dermatite atópica a 36 semanas de gestação. Resultados A exposição pré-natal, porém não pós-natal, ao mofo foi significativamente associada à dermatite atópica (razão de chances ajustada, 1,36; intervalo de confiança de 95%, 1,01-1,83). Os níveis séricos totais de Imunoglobulina E (IgE) no primeiro ano de vida foram maiores em neonatos com dermatite atópica expostos a mofo durante a gravidez do que em neonatos não expostos a mofo durante a gravidez (p = 0,021). A abundância relativa de Ascomycota não cultivado foi maior em neonatos com dermatite atópica do que em neonatos saudáveis. A abundância relativa de Ascomycota não cultivado correlacionou-se com os níveis séricos totais de IgE no primeiro ano de vida (r = 0,613, p < 0,001). Conclusão A exposição ao mofo no ambiente domiciliar durante a gravidez está associada ao desenvolvimento de dermatite atópica por meio de reação alérgica mediada por IgE. A prevenção à exposição ao mofo durante o período crítico da gravidez pode prevenir o desenvolvimento de dermatite atópica.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Asthma / Dermatitis, Atopic / Inflammation Type of study: Controlled clinical trial / Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Child / Female / Humans / Infant / Pregnancy Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2020 Type: Article Affiliation country: South Korea Institution/Affiliation country: CHA Medical Center/KR / Chonnam National University Hospital/KR / International St. Mary's Hospital/KR / Mediplex Sejong Hospital/KR / Pusan National University/KR / Seoul National University College of Medicine/KR / Sungkyunkwan University/KR / University of Ulsan College of Medicine/KR / Yonsei University/KR

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Full text: Available Index: LILACS (Americas) Main subject: Asthma / Dermatitis, Atopic / Inflammation Type of study: Controlled clinical trial / Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Child / Female / Humans / Infant / Pregnancy Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2020 Type: Article Affiliation country: South Korea Institution/Affiliation country: CHA Medical Center/KR / Chonnam National University Hospital/KR / International St. Mary's Hospital/KR / Mediplex Sejong Hospital/KR / Pusan National University/KR / Seoul National University College of Medicine/KR / Sungkyunkwan University/KR / University of Ulsan College of Medicine/KR / Yonsei University/KR