Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum
Rev. Soc. Bras. Med. Trop
;
53: e20190155, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1092219
ABSTRACT
Abstract INTRODUCTION:
Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these mutations are infrequent in the genus Ascaris spp.METHODS:
In order to determine mutations associated with benzimidazole resistance in Ascaris suum, worms were collected from slaughtered pigs and a partial region of the β-tubulin gene was sequenced.RESULTS:
All parasites showed the wildtype genotype for codons 167, 198, and 200 of the β-tubulin gene.CONCLUSIONS:
This is the first report of genetic sequences associated with benzimidazole resistance in A. suum.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Benzimidazoles
/
Drug Resistance
/
Ascaris suum
/
Mutation
Type of study:
Risk factors
Limits:
Animals
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2020
Type:
Article
Affiliation country:
Canada
/
Honduras
Institution/Affiliation country:
Brock University/CA
/
Universidad Nacional Autónoma de Honduras (UNAH)/HN
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