Effect of Camellia sinensis teas on left ventricular hypertrophy and insulin resistance in dyslipidemic mice
Braz. j. med. biol. res
;
53(5): e9303, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1098109
ABSTRACT
The control of dyslipidemia using plants is an important subject of studies since it has numerous benefits in cardiovascular protection. The objective of this study was to evaluate the effect of three Camellia sinensis L. teas (green, red, and white) on left ventricular hypertrophy and insulin resistance in low-density lipoprotein receptor knockout (LDLr-/-) mice fed a high-fat diet. The LDLr-/- mice were divided into four experimental groups Group C standard feed; Group CT standard feed and three teas, Group HL high-fat feed; HLT Group high-fat feed and three teas. The three types of tea (green, red, and white) originated from different processing of the Camellia sinensis L. plant, and were administered associated once a day at a dose of 25 mg/kg by gavage for 60 days. The teas partially prevented hyperlipidemia, the decrease of the serum levels of high-density lipoproteins (HDL), insulin resistance, and increased C-reactive protein (CRP) levels, and completely prevented left ventricular hypertrophy in LDLr -/- mice of the HLT group. In conclusion, the three Camellia sinensis L. teas used to control genetic dyslipidemia associated with a high-fat diet can be used as an auxiliary treatment associated with the control of lipid intake, thus promoting cardiac protection against hyperlipidemia.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Insulin Resistance
/
Plant Extracts
/
Hypertrophy, Left Ventricular
/
Camellia sinensis
/
Dyslipidemias
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto Federal do Sul de Minas/BR
/
Universidade José do Rosário Vellano/BR
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