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Donación dirigida de sangre de Cordón Umbilical de Hermano Compatible en el Sistema de Salud Público de Chile / Directed sibling donor cord blood donation in the Chilean Public Health System
Sotomayor, Cristián; Salas, Lucía; Lattus, José; Anguita-Compagnon, Alfonso T; Abarzúa, Carolina; Catalán, Paula; Palma, Julia.
  • Sotomayor, Cristián; Hospital Dr. Luís calvo Mackenna. Unidad de trasplante de Médula Ósea. Santiago. CL
  • Salas, Lucía; Hospital Dr. Luís calvo Mackenna. Unidad de trasplante de Médula Ósea. Santiago. CL
  • Lattus, José; Hospital Dr. Luís Tisné. Santiago. CL
  • Anguita-Compagnon, Alfonso T; Clínica Alemana de Santiago. Laboratorio de trasplante. Santiago. CL
  • Abarzúa, Carolina; Hospital Dr. Luís calvo Mackenna. Unidad de trasplante de Médula Ósea. Santiago. CL
  • Catalán, Paula; Hospital Dr. Luís calvo Mackenna. Unidad de trasplante de Médula Ósea. Santiago. CL
  • Palma, Julia; s.af
Rev. chil. pediatr ; 91(2): 226-231, abr. 2020. tab
Article in Spanish | LILACS | ID: biblio-1098895
RESUMEN
Resumen

Introducción:

La sangre de cordón umbilical (SCU) como fuente para trasplante de células proge- nitoras hematopoyéticas (TPH) está bien establecida. Internacionalmente, menos del 10% de los TPH de SCU corresponde a donantes hermanos compatibles. Dentro de la red del Programa Infantil Nacional de Drogas Antineoplásicas (PINDA), existe desde enero 2004 un programa de donación dirigida de SCU para TPH. Pacientes y

Método:

Se diseñó un estudio observacional, retrospectivo, descriptivo, se revisaron el número y características de las unidades de SCU recolectadas en el PINDA y el número, características y evolución de los pacientes trasplantados con esas unidades entre enero de 2004 y octubre de 2018.

Resultados:

Sesenta unidades de SCU han sido recolectadas, de ellas 55 con registro completo. La mediana de volumen de las unidades almacenadas fue 74,8 ml (30,0-170,8), la mediana de células nucleadas totales 7,6 x 10e8 (2,0-21,1), mediana de células CD34+ 1,6 x 10e6 (0,2-11,6). Cuatro pacientes con leucemias de alto riesgo fueron trasplantados; mediana de segui miento es de 8 años. Todos desarrollaron complicaciones severas post TPH, uno de ellos falleció de recaída y los tres actualmente vivos presentan un Karnofsky/Lansky 100%.

Conclusión:

El programa ha permitido el trasplante de 4 pacientes que de otro modo no habrían tenido acceso a un donante. Este programa de donación dirigida puede ser considerado una primera etapa para el desarrollo de un banco público de sangre de cordón umbilical en Chile.
ABSTRACT
Abstract

Introduction:

Cord blood (CB) as a source of Hematopoietic Stem Cells for Transplantation (HSCT) is well established. Worldwide, nonetheless, less than 10% of the CB HSCTs are performed with a match sibling donor. Since 2004, the Chilean National Childhood Cancer Program (PINDA) net work, has established a CB directed donation program for HSCT. Patients and

Method:

An obser vational, descriptive and retrospective study was designed to assess the number and characteristics of the CB units collected in the program as well as the number, clinical characteristics and follow-up of the patients who received an HSCT from those CB units between January 2004 and October 2018.

Results:

Sixty CB units have been collected; 55 of them with full records and stored. The median volume collected was 74.8 ml (30.0-170.8), the median number of total nucleated cells was 7.6 x 10e8 (2.0-21.1), and the median of CD34+ cells was 1.6 x 10e6 (0.2-11.6). Four high-risk leukemia patients received HSCT, all of them developed severe complications after transplantation and one patient died due to relapse. Those patients currently alive have a 100% Karnofsky/Lansky score. The median follow-up time was 8 years.

Conclusion:

The PINDA program has allowed 4 patients to be transplan ted who otherwise would not have had access to a donor. This directed donation program could be seen as a model for the development of a public cord blood bank in Chile.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Blood Donors / Hematopoietic Stem Cell Transplantation / Siblings / Directed Tissue Donation / Fetal Blood Type of study: Observational study / Prognostic study / Risk factors Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. chil. pediatr Journal subject: Pediatrics Year: 2020 Type: Article Affiliation country: Chile Institution/Affiliation country: Clínica Alemana de Santiago/CL / Hospital Dr. Luís Tisné/CL / Hospital Dr. Luís calvo Mackenna/CL

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Full text: Available Index: LILACS (Americas) Main subject: Blood Donors / Hematopoietic Stem Cell Transplantation / Siblings / Directed Tissue Donation / Fetal Blood Type of study: Observational study / Prognostic study / Risk factors Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. chil. pediatr Journal subject: Pediatrics Year: 2020 Type: Article Affiliation country: Chile Institution/Affiliation country: Clínica Alemana de Santiago/CL / Hospital Dr. Luís Tisné/CL / Hospital Dr. Luís calvo Mackenna/CL