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Effectiveness and safety of protease inhibitors for the hepatitis C treatment in a hospital of South Brazil: real life data
Mattana, Aline Bianca Borba; Schwambach, Karin Hepp; Feltrin, Alberi Adolfo; Farias, Mareni Rocha; Blatt, Carine Raquel.
  • Mattana, Aline Bianca Borba; Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA). Porto Alegre. BR
  • Schwambach, Karin Hepp; Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA). Porto Alegre. BR
  • Feltrin, Alberi Adolfo; Grupo Hospitalar Conceição. Centros de Aplicação e Monitorização de Medicamentos Injetáveis (CAMMI). Porto Alegre. BR
  • Farias, Mareni Rocha; Universidade Federal de Santa Catarina (UFSC). Florianópolis. BR
  • Blatt, Carine Raquel; Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA). Porto Alegre. BR
Rev. ciênc. farm. básica apl ; 3901/01/2018. tab, ilus
Article in English | LILACS | ID: biblio-1100213
ABSTRACT
The combination of Inhibitors of protease boceprevir (BOC) or telaprevir (TLV) concomitantly with peginterferon (PEG) and ribavirin (RBV) constitute the triple therapy (TT) for Hepatitis C treatment.

Objective:

To describe the experience of the TT treatment of chronic hepatitis C patients, besides discussing safety issues, in real life.

Methods:

Observational and retrospective study with 180 patients attended in a specialized center, between July 2014 and December 2015. Were evaluated variables as gender, age, access to drugs, pattern of alcohol consumption, pathway of contamination reported by the patient, previous treatment, degree of fibrosis, treatment regimen, treatment interruption and reason and Sustained Viral Response (SVR). Adverse Drug Reactions (ADRs) were collect through monthly self-report by the patient to the pharmacist.

Results:

65 patients used BOC and 115 TLV, and the mean age was 54.20 (BOC) and 53.92 (TLV) years. End of treatment rate was 52.3% (BOC) and 53.3% (TLV). ADRs occurred in 18.5% of the patients (BOC) and 13.9% (TLV), being more frequent the severe anemia. Erythropoietin (EPO) used in 45.4% (BOC) and 58.2% (TLV). SVR rate calculated by intention to treat was 38.5% (BOC) e 50.4% (TLV).

Conclusion:

This study has shown that the effectiveness of TT is not significantly higher than double therapy and is lower than the reported in clinical trials. High dropout rates due to ADRs have been demonstrated, as well as a lower SVR found in clinical trials.(AU)
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Protease Inhibitors / Ribavirin / Hepatitis C, Chronic / Interferon alpha-2 Type of study: Observational study Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. ciênc. farm. básica apl Journal subject: Pharmacology Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Grupo Hospitalar Conceição/BR / Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)/BR / Universidade Federal de Santa Catarina (UFSC)/BR

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Full text: Available Index: LILACS (Americas) Main subject: Protease Inhibitors / Ribavirin / Hepatitis C, Chronic / Interferon alpha-2 Type of study: Observational study Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. ciênc. farm. básica apl Journal subject: Pharmacology Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Grupo Hospitalar Conceição/BR / Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)/BR / Universidade Federal de Santa Catarina (UFSC)/BR