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The effects of intro-oral parathyroid hormone on the healing of tooth extraction socket: an experimental study on hyperglycemic rats
XU, Lin; MEI, Li; ZHAO, Rui; YI, Jianru; JIANG, Yixuan; LI, Ruomei; ZHAO, Youliang; PI, Li; LI, Yu.
  • XU, Lin; Sichuan University. West China Hospital of Stomatology. National Clinical Research Center for Oral Diseases. Chengdu. CN
  • MEI, Li; University of Otago. Faculty of Dentistry. Sir John Walsh Research Institute. NZ
  • ZHAO, Rui; Sichuan University. West China Hospital of Stomatology. National Clinical Research Center for Oral Diseases. Chengdu. CN
  • YI, Jianru; Sichuan University. West China Hospital of Stomatology. National Clinical Research Center for Oral Diseases. Chengdu. CN
  • JIANG, Yixuan; Sichuan University. West China Hospital of Stomatology. National Clinical Research Center for Oral Diseases. Chengdu. CN
  • LI, Ruomei; Shanghai Jiao Tong University. School of Stomatology. Ninth People's Hospital. Shanghai. CN
  • ZHAO, Youliang; Sichuan University. West China Second Hospital. Department of emergency department. Chengdu. CN
  • PI, Li; Sichuan University. West China School of Public Health. Chengdu. CN
  • LI, Yu; Sichuan University. West China Hospital of Stomatology. National Clinical Research Center for Oral Diseases. Chengdu. CN
J. appl. oral sci ; 28: e20190690, 2020. graf
Article in English | LILACS, BBO | ID: biblio-1101255
ABSTRACT
Abstract Objective To investigate the effects of intro-oral injection of parathyroid hormone (PTH) on tooth extraction wound healing in hyperglycemic rats. Methodology 60 male Sprague-Dawley rats were randomly divided into the normal group (n=30) and DM group (n=30). Type 1 diabetes mellitus (DM) was induced by streptozotocin. After extracting the left first molar of all rats, each group was further divided into 3 subgroups (n=10 per subgroup), receiving the administration of intermittent PTH, continuous PTH and saline (control), respectively. The intermittent-PTH group received intra-oral injection of PTH three times per week for two weeks. A thermosensitive controlled-release hydrogel was synthesized for continuous-PTH administration. The serum chemistry was determined to evaluate the systemic condition. All animals were sacrificed after 14 days. Micro-computed tomography (Micro-CT) and histological analyses were used to evaluate the healing of extraction sockets. Results The level of serum glucose in the DM groups was significantly higher than that in the non-DM groups (p<0.05); the level of serum calcium was similar in all groups (p>0.05). Micro-CT analysis showed that the DM group had a significantly lower alveolar bone trabecular number (Tb.N) and higher trabecular separation (Tb.Sp) than the normal group (p<0.05). The histological analyses showed that no significant difference in the amount of new bone (hard tissue) formation was found between the PTH and non-PTH groups (p>0.05). Conclusions Bone formation in the extraction socket of the type 1 diabetic rats was reduced. PTH did not improve the healing of hard and soft tissues. The different PTH administration regimes (continuous vs. intermittent) had similar effect on tissue healing. These results demonstrated that the metabolic characteristics of the hyperglycemic rats produced a condition that was unable to respond to PTH treatment.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Parathyroid Hormone / Tooth Extraction / Wound Healing / Tooth Socket / Diabetes Mellitus, Experimental Type of study: Evaluation studies Limits: Animals Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2020 Type: Article Affiliation country: China / New Zealand Institution/Affiliation country: Shanghai Jiao Tong University/CN / Sichuan University/CN / University of Otago/NZ

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Full text: Available Index: LILACS (Americas) Main subject: Parathyroid Hormone / Tooth Extraction / Wound Healing / Tooth Socket / Diabetes Mellitus, Experimental Type of study: Evaluation studies Limits: Animals Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2020 Type: Article Affiliation country: China / New Zealand Institution/Affiliation country: Shanghai Jiao Tong University/CN / Sichuan University/CN / University of Otago/NZ