Presence of Type 1 Collagen Alpha-2 (COL1A2) (rs42524) Gene Polymorphism and Scar Tissue Formation in Different Areas of Head and Neck
Pesqui. bras. odontopediatria clín. integr
;
20: e4422, 2020. tab
Article
in English
| BBO, LILACS
| ID: biblio-1101295
ABSTRACT
Abstract Objective:
To determine the effect type I collagen gene polymorphism alpha-2 (COL1A2) (rs42524) on the formation of scar tissue that is localized in the head and neck areas. Material andMethods:
Sixty patients with scars in different areas of the head and neck were examined. The patients were divided into four subgroups, according to the types of scarring G I 15 patients with normotrophic scars; G ІІ 15 patients with atrophic scars; G ІІІ 15 patients with hypertrophic scars; and G IV 15 patients with keloid scars. The age of patients ranged from 17 to 54 years. The single-nucleotide polymorphic site of the COL1A2 (rs42524) gene was detected by a polymerase chain reaction and subsequent analysis of restriction fragment lengths. Pearson's chi-squared test with Yates's correction and Fischer's exact test were used.Results:
There were no significant changes between the control and basic groups (p=0.83) at analyzing the frequencies of G and C alleles. For the G allele, the calculation of odds ratio between the basic and control groups was 0.93 at 95% confidence interval (CI) (0.50-1.75), for the C allele - OR was 1.07 at 95% CI (0.57-2.01).Conclusion:
Our studies may indirectly indicate the activation of the skin's protective reaction to physiological scarring and dosed scar formation in different areas of the head and neck.
Full text:
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Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Polymerase Chain Reaction
/
Cicatrix, Hypertrophic
/
Collagen Type I
/
Head
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
English
Journal:
Pesqui. bras. odontopediatria clín. integr
Journal subject:
Dentistry
Year:
2020
Type:
Article
Affiliation country:
Ukraine
Institution/Affiliation country:
Ukrainian Medical Stomatological Academy/UA
/
Uzhgorod National University/UA
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