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Presence of Type 1 Collagen Alpha-2 (COL1A2) (rs42524) Gene Polymorphism and Scar Tissue Formation in Different Areas of Head and Neck
Avetikov, David Solomonovich; Buchanhenko, Olga Petrivna; Shlykova, Oksana Anatoliivna; Izmajlova, Olga Vitaliivna; Lokes, Kateryna Petrivna; Klitynska, Oksana Vasylivna; Vesnina, Ludmila Eduardivna; Kajdashev, Igor Petrovich.
  • Avetikov, David Solomonovich; Ukrainian Medical Stomatological Academy. Department of Surgical Stomatology and Maxillo-Facial Surgery with Plastic and Reconstructive Surgery of Head and Neck. Poltava. UA
  • Buchanhenko, Olga Petrivna; Ukrainian Medical Stomatological Academy. Department of Surgical Stomatology and Maxillo-Facial Surgery with Plastic and Reconstructive Surgery of Head and Neck. Poltava. UA
  • Shlykova, Oksana Anatoliivna; Ukrainian Medical Stomatological Academy. Research Institute of Genetic and Immunological Foundations of Pathology and Pharmacogenetics Development. Poltava. UA
  • Izmajlova, Olga Vitaliivna; Ukrainian Medical Stomatological Academy. Research Institute of Genetic and Immunological Foundations of Pathology and Pharmacogenetics Development. Poltava. UA
  • Lokes, Kateryna Petrivna; Ukrainian Medical Stomatological Academy. Department of Surgical Stomatology and Maxillo-Facial Surgery with Plastic and Reconstructive Surgery of Head and Neck. Poltava. UA
  • Klitynska, Oksana Vasylivna; Uzhgorod National University. Department of Stomatology of Child Age. Uzhgorod. UA
  • Vesnina, Ludmila Eduardivna; Ukrainian Medical Stomatological Academy. Research Institute of Genetic and Immunological Foundations of Pathology and Pharmacogenetics Development. Poltava. UA
  • Kajdashev, Igor Petrovich; Ukrainian Medical Stomatological Academy. Poltava. UA
Pesqui. bras. odontopediatria clín. integr ; 20: e4422, 2020. tab
Article in English | BBO, LILACS | ID: biblio-1101295
ABSTRACT
Abstract

Objective:

To determine the effect type I collagen gene polymorphism alpha-2 (COL1A2) (rs42524) on the formation of scar tissue that is localized in the head and neck areas. Material and

Methods:

Sixty patients with scars in different areas of the head and neck were examined. The patients were divided into four subgroups, according to the types of scarring G I 15 patients with normotrophic scars; G ІІ 15 patients with atrophic scars; G ІІІ 15 patients with hypertrophic scars; and G IV 15 patients with keloid scars. The age of patients ranged from 17 to 54 years. The single-nucleotide polymorphic site of the COL1A2 (rs42524) gene was detected by a polymerase chain reaction and subsequent analysis of restriction fragment lengths. Pearson's chi-squared test with Yates's correction and Fischer's exact test were used.

Results:

There were no significant changes between the control and basic groups (p=0.83) at analyzing the frequencies of G and C alleles. For the G allele, the calculation of odds ratio between the basic and control groups was 0.93 at 95% confidence interval (CI) (0.50-1.75), for the C allele - OR was 1.07 at 95% CI (0.57-2.01).

Conclusion:

Our studies may indirectly indicate the activation of the skin's protective reaction to physiological scarring and dosed scar formation in different areas of the head and neck.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Polymerase Chain Reaction / Cicatrix, Hypertrophic / Collagen Type I / Head Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Pesqui. bras. odontopediatria clín. integr Journal subject: Dentistry Year: 2020 Type: Article Affiliation country: Ukraine Institution/Affiliation country: Ukrainian Medical Stomatological Academy/UA / Uzhgorod National University/UA

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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Polymerase Chain Reaction / Cicatrix, Hypertrophic / Collagen Type I / Head Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Pesqui. bras. odontopediatria clín. integr Journal subject: Dentistry Year: 2020 Type: Article Affiliation country: Ukraine Institution/Affiliation country: Ukrainian Medical Stomatological Academy/UA / Uzhgorod National University/UA