Your browser doesn't support javascript.
loading
Evaluation of the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats
Aydin, Emre; Yildirim, Yasar; Aydin, Fatma Yilmaz; Bahadir, Mehmet Veysi; Kaplan, Ibrahim; Kadiroglu, Berfin; Ketani, Muzaffer Aydin; Yilmaz, Zülfükar; Kadiroglu, Ali Kemal; Yilmaz, Mehmet Emin.
Affiliation
  • Aydin, Emre; University of Dicle. School of Medicine. Department of Nephrology. Diyarbakir. TR
  • Yildirim, Yasar; University of Dicle. School of Medicine. Department of Nephrology. Diyarbakir. TR
  • Aydin, Fatma Yilmaz; University of Dicle. School of Medicine. Department of Internal Medicine. Diyarbakir. TR
  • Bahadir, Mehmet Veysi; University of Dicle. School of Medicine. Department of General Surgery. Diyarbakir. TR
  • Kaplan, Ibrahim; University of Dicle. School of Medicine. Department of Biochemistry. Diyarbakir. TR
  • Kadiroglu, Berfin; University of Dicle. School of Veterinary Medicine. Department of Virology. Diyarbakir. TR
  • Ketani, Muzaffer Aydin; University of Dicle. School of Veterinary Medicine. Department of Histology and Embryology. Diyarbakir. TR
  • Yilmaz, Zülfükar; University of Dicle. School of Medicine. Department of Nephrology. Diyarbakir. TR
  • Kadiroglu, Ali Kemal; University of Dicle. School of Medicine. Department of Nephrology. Diyarbakir. TR
  • Yilmaz, Mehmet Emin; University of Dicle. School of Medicine. Department of Nephrology. Diyarbakir. TR
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;53: e20200016, 2020. tab, graf
Article in En | LILACS | ID: biblio-1101450
Responsible library: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

Sepsis is an important cause of mortality and morbidity, and inflammatory response and oxidative stress play major roles underlying its pathophysiology. Here, we evaluated the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats.

METHODS:

Twenty-eight adult Sprague Dawley rats were classified into Control (Group 1), Sepsis (Group 2), Sepsis+Cefazolin (Group 3), and Sepsis+Cefazolin+Etanercept (Group 4) groups. Kidney tissue and serum samples were obtained for biochemical and histopathological investigations and examined for the C reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), triggering receptor expressed on myeloid cells (TREM), and malondialdehyde (MDA) levels.

RESULTS:

The levels of TNF-α, TREM, and MDA in serum and kidney samples were significantly higher in rats from sepsis group than in rats from control group (p < 0.05). Group 3 showed a significant reduction in serum levels of TNF-α, CRP, and TREM as compared with Group 2 (p < 0.05). Serum TNF-α, CRP, TREM, and MDA levels and kidney TNF-α and TREM levels were significantly lower in Group 4 than in Group 2 (p < 0.05). Serum TNF-α and TREM levels in Group 4 were significantly lower than those in Group 3, and histopathological scores were significantly lower in Group 3 and Group 4 than in Group 2 (p < 0.05). Histopathological scores of Group 4 were significantly lower than those of Group 3 (p < 0.05).

CONCLUSIONS:

Etanercept, a TNF-α inhibitor, may ameliorate sepsis-induced oxidative stress, inflammation, and histopathological damage.
Subject(s)
Key words

Full text: 1 Index: LILACS Main subject: Anti-Inflammatory Agents, Non-Steroidal / Tumor Necrosis Factor-alpha / Sepsis / Oxidative Stress / Etanercept / Inflammation / Kidney Type of study: Prognostic_studies Limits: Animals Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2020 Type: Article

Full text: 1 Index: LILACS Main subject: Anti-Inflammatory Agents, Non-Steroidal / Tumor Necrosis Factor-alpha / Sepsis / Oxidative Stress / Etanercept / Inflammation / Kidney Type of study: Prognostic_studies Limits: Animals Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2020 Type: Article