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Adverse drug events and the associated factors in patients with chronic Chagas disease
Lopes, Luiza Braz da Cunha; Pereira, Raquel Rodrigues; Andrade, Patricia Mello; Carneiro, Fernanda Martins; Mediano, Mauro Felippe Felix; Kilgore, Sophia Isabel Linnemann; Hasslocher-Moreno, Alejandro Marcel; Sousa, Andréa Silvestre de; Oliveira, Manoel Marques Evangelista; Saraiva, Roberto Magalhães; Holanda, Marcelo Teixeira de; Silva, Gilberto Marcelo Sperandio da.
  • Lopes, Luiza Braz da Cunha; Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro. BR
  • Pereira, Raquel Rodrigues; Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro. BR
  • Andrade, Patricia Mello; Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro. BR
  • Carneiro, Fernanda Martins; Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro. BR
  • Mediano, Mauro Felippe Felix; Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro. BR
  • Kilgore, Sophia Isabel Linnemann; Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro. BR
  • Hasslocher-Moreno, Alejandro Marcel; Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro. BR
  • Sousa, Andréa Silvestre de; Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro. BR
  • Oliveira, Manoel Marques Evangelista; Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro. BR
  • Saraiva, Roberto Magalhães; Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro. BR
  • Holanda, Marcelo Teixeira de; Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro. BR
  • Silva, Gilberto Marcelo Sperandio da; Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro. BR
Rev. Soc. Bras. Med. Trop ; 53: e20190443, 2020. tab
Article in English | LILACS | ID: biblio-1101452
ABSTRACT
Abstract

INTRODUCTION:

Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients.

METHODS:

We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs.

RESULTS:

ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs.

CONCLUSIONS:

Close follow-up is warranted for CD patients.
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Full text: Available Index: LILACS (Americas) Main subject: Chagas Disease / Drug-Related Side Effects and Adverse Reactions Type of study: Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz/BR

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Full text: Available Index: LILACS (Americas) Main subject: Chagas Disease / Drug-Related Side Effects and Adverse Reactions Type of study: Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz/BR