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Investigation of polysaccharide extracts from Iranian and French strains of Agaricus subrufescens against enzymes involved in Alzheimer's disease / Investigación de extractos de polisacáridos de cepas iraníes y francesas de Agaricus subrufescens contra enzimas relevantes para la enfermedad de Alzheimer
Rahmani-Nezhad, Samira; Dianat, Shima; Mahdizadeh, Valiollah; Fooladi, Zahra; Hariri, Roshanak; Najafi, Zahra; Firuzi, Omidreza; Vahedi-Mazdabadi, Yasaman; Farjadmand, Fatemeh; Akbarzadeh, Tahmineh; Saeedi, Mina; Ardekan, Mohammadreza Shams.
  • Rahmani-Nezhad, Samira; Tehran University of Medical Sciences. Faculty of Pharmacy. Medicinal Plants Research Center. IR
  • Dianat, Shima; Tehran University of Medical Sciences. Faculty of Pharmacy. Medicinal Plants Research Center. IR
  • Mahdizadeh, Valiollah; Tarbiat Modares University. Faculty of Agriculture. Department of Plant Pathology. IR
  • Fooladi, Zahra; Tehran University of Medical Sciences. Faculty of Pharmacy. Department of Pharmacognosy. IR
  • Hariri, Roshanak; Tehran University of Medical Sciences. Faculty of Pharmacy. Department of Medicinal Chemistry. IR
  • Najafi, Zahra; Hamadan University of Medical Sciences. School of Pharmacy. Department of Medicinal Chemistry. IR
  • Firuzi, Omidreza; Shiraz University of Medical Sciences. Medicinal and Natural Products Chemistry Research Center. IR
  • Vahedi-Mazdabadi, Yasaman; Tehran University of Medical Sciences. Persian Medicine and Pharmacy Research Center. IR
  • Farjadmand, Fatemeh; Tehran University of Medical Sciences. Persian Medicine and Pharmacy Research Center. IR
  • Akbarzadeh, Tahmineh; Tehran University of Medical Sciences. Faculty of Pharmacy. Department of Medicinal Chemistry. IR
  • Saeedi, Mina; Tehran University of Medical Sciences. Faculty of Pharmacy. Medicinal Plants Research Center. IR
  • Ardekan, Mohammadreza Shams; Tehran University of Medical Sciences. Faculty of Pharmacy. Department of Pharmacognosy. IR
Bol. latinoam. Caribe plantas med. aromát ; 18(6): 544-554, nov. 2019. tab, ilus
Article in English | LILACS | ID: biblio-1102238
Responsible library: CL1.1
ABSTRACT
In this work, the inhibitory activity of a wide range of polysaccharide extracts from two Iranian and French strains of Agaricus subrufescens were evaluated toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Among them, two extracts S9 and S'7 obtained from Iranian and French strains under different extraction conditions showed selective AChE inhibitory activity with IC50 values of 154.63 and 145.43 µg/mL, respectively. It should be noted that all extracts from both strains demonstrated no BChE inhibitory activity. S9 and S'7 were also tested for their effect on amyloid beta (Aß) aggregation, antioxidant activity, and neuroprotectivity. Their activity against Aß aggregation was comparable to that of donepezil as the reference drug but they induced moderate antioxidant activity by DPPH radical scavenging activity and negligible neuroprotectivity against Aß-induced damage.
RESUMEN
En este trabajo, se evaluó la actividad inhibitoria de acetilcolinesterasa (AChE) y butirilcolinesterasa (BChE) para varios extractos de polisacáridos de dos cepas iraníes y francesas de Agaricus subrufescens. Los extractos más potentes mostraron valores de IC50 de 154,63 y 145 µg/ml para las cepas iraní (S9) y francesa (S'7), respectivamente, las cuales se obtuvieron de diferentes condiciones de extracción; sin embargo, todos los extractos no mostraron actividad inhibitoria de BChE. Además, S9 y S'7 se probaron para determinar su efecto sobre la agregación de beta-amiloide (Aß), así como su actividad antioxidante y neuroprotectora. Su actividad inhibitoria de la agregación de Aß fue comparable con donepezil, fármaco de referencia, pero indujeron una actividad antioxidante moderada, medida mediante la captación de radicales DPPH, y una neuroprotectora insignificante contra el daño inducido por Aß.
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Full text: Available Index: LILACS (Americas) Main subject: Agaricus / Alzheimer Disease / Amyloid / Antioxidants Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Hamadan University of Medical Sciences/IR / Shiraz University of Medical Sciences/IR / Tarbiat Modares University/IR / Tehran University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Agaricus / Alzheimer Disease / Amyloid / Antioxidants Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Hamadan University of Medical Sciences/IR / Shiraz University of Medical Sciences/IR / Tarbiat Modares University/IR / Tehran University of Medical Sciences/IR