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Larvicidal activity of piperovatine and dichloromethane extract from Piper corcovadensis roots against mosquitoes Aedes aegypti L / Actividad larvicida de piperovatina y extracto de diclorometano de las raíces de Piper corcovadensis contra mosquitos vectores del dengue Aedes aegypti L
Fernandez, Carla Maria Mariano; Lorenzetti, Fabiana Brusco; Lima, Marli Miriam de Souza; Kleinubing, Sirlene Adriana; Bortolucci, Wanessa de Campos; Andrade, João Paulo Pinguello de; Romagnolo, Mariza Barion; Cortez, Diógenes Aparício Garcia; Gazim, Zilda Cristiani; Filho, Benedito Prado Dias.
  • Fernandez, Carla Maria Mariano; State University of Maringá. Postgraduate Program in Pharmaceutical Sciences. Maringá. BR
  • Lorenzetti, Fabiana Brusco; State University of Maringá. Postgraduate Program in Pharmaceutical Sciences. Maringá. BR
  • Lima, Marli Miriam de Souza; State University of Maringá. Postgraduate Program in Pharmaceutical Sciences. Maringá. BR
  • Kleinubing, Sirlene Adriana; State University of Maringá. Postgraduate Program in Pharmaceutical Sciences. Maringá. BR
  • Bortolucci, Wanessa de Campos; Paranaense University. Postgraduate Program in Biotechnology Applied to the Agriculture. Umuarama. BR
  • Andrade, João Paulo Pinguello de; State University of Western Paraná. Postgraduate Program in Chemical Engineering. BR
  • Romagnolo, Mariza Barion; State University of Maringá. Departament of Biology. Maringá. BR
  • Cortez, Diógenes Aparício Garcia; State University of Maringá. Postgraduate Program in Pharmaceutical Sciences. Maringá. BR
  • Gazim, Zilda Cristiani; Paranaense University. Postgraduate Program in Biotechnology Applied to the Agriculture. Umuarama. BR
  • Filho, Benedito Prado Dias; State University of Maringá. Postgraduate Program in Pharmaceutical Sciences. Maringá. BR
Bol. latinoam. Caribe plantas med. aromát ; 19(1): 142-148, ene. 2020. ilus, tab
Article in English | LILACS | ID: biblio-1103091
ABSTRACT
The research of new substances capable of controlling the Aedes aegypti mosquito is urgent due to the increase in the transmission of the diseases such as dengue, chikungunya and Zika virus by the vector. Thus, the aim of this study was to evaluate the larvicidal activity of crude extract of Piper corcovadensis roots, a native plant from Brazil, and of the isolated compound piperovatine against larvae of A. aegypti by the larval immersion test. The lethal concentration that killed 50% (LC50) and 99% (LC99) of larvae was determined by Probit analysis. The results indicated high larvicidal activity on A. aegypti larvae for crude extract of Piper corcovadensis roots with LC50 of 4.86 µg/mL and LC99 of 15.50 µg/mL and piperovatine with LC50 of 17.78 µg/mL and LC99 of 48.55 µg/mL. This work opens new perspectives to the development of future products with crude extract of Piper corcovadensis roots and piperovatine that can be applied to mosquito control.
RESUMEN
La investigación de nuevas sustancias capaces de controlar el mosquito Aedes aegypti es urgente debido al aumento en la transmisión de enfermedades como el dengue, el chikungunya y el virus Zika por el vector. Por lo tanto, el objetivo de este estudio fue evaluar la actividad larvicida del extracto crudo de las raíces de Piper corcovadensis, una planta nativa de Brasil, y del compuesto aislado piperovatine contra larvas de A. aegypti mediante la prueba de inmersión larvaria. La concentración letal que mató al 50% (LC50) y al 99% (LC99) de larvas se determinó mediante análisis Probit. Los resultados indicaron una alta actividad larvicida en larvas de A. aegypti para extracto crudo de las raíces de Piper corcovadensis con LC50 de 4.86 µg/mL y LC99 de 15.50 µg/mL y piperovatine con LC50 de 17.78 µg/mL y LC99 de 48.55 µg/mL. Este trabajo abre nuevas perspectivas para el desarrollo de futuros productos con extracto crudo de las raíces de Piper corcovadensis y piperovatine que pueden aplicarse al control de mosquitos.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Sorbic Acid / Plant Extracts / Aedes / Piper / Insecticides Limits: Animals Country/Region as subject: South America / Brazil Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Paranaense University/BR / State University of Maringá/BR / State University of Western Paraná/BR

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Full text: Available Index: LILACS (Americas) Main subject: Sorbic Acid / Plant Extracts / Aedes / Piper / Insecticides Limits: Animals Country/Region as subject: South America / Brazil Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Paranaense University/BR / State University of Maringá/BR / State University of Western Paraná/BR