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Defecto osteocondral de cóndilo femoral. Estudio experimental en ratas / Osteochondral defect of femoral condyle. Experimental study in rats
Lima; s.n; 2013. [29] p. ilus, tab.
Thesis in Spanish | LILACS, LIPECS | ID: biblio-1113171
RESUMEN

Objetivo:

Determinar si hay reparación de defectos osteocondrales en cóndilos femorales usando cartílago costal e injerto de cresta iliaca autólogos en ratas blancas. Material y

métodos:

Se experimentó con 60 ratas blancas de entre 110 y 120 gr. Se formaron dos grupos de 30 especímenes cada uno (control y experimental). Al control solo se le hizo la exceresis del cóndilo femoral medial y al grupo experimental, además, se colocó cartílago costal sobre el defecto con injerto de cresta iliaca interpuesto, ambos autólogos. Los especímenes fueron sacrificados a los 60 días y evaluados microscópicamente.

Resultados:

Se usó el test de t-student. Hubo diferencia significativa entre los grupos control y experimental, considerando el puntaje total de las cinco variables estudiadas. Así mismo se encontró diferencia significativa con la variable morfología celular; con las variables metacromasia, regularidad de superficie, grosor del cartílago e integración con el cartílago adyacente, no se encontró diferencia significativa.

Conclusiones:

No hubo reparación de los defectos osteocondrales amplios de los cóndilos femorales.
ABSTRACT
Objetive Determine if osteochondral femoral defect will be repaired using costal cartilage and autologous iliac crest graft in rats.

Material:

We experimented with 60 white rats of 110 and 120 gr. Two groups of 30 specimens (control and experimental). By controlling onIy the exeresis him the medial femoral condyle and the experimental group, in addition, costal cartilage was placed over the defect with iliac crest graft interposed, both autologous. Specimens were sacrificed at 60 days and evaluated microscopically.

Results:

It was used student's-t test. There was significant difference between the control and experimental groups, considering the total score of the five variables. Also significant differences were found with variable cell morphology, with metachromasia variables, surface regularity, thickness of cartilage and integration with adjacent cartilage, no significant difference was found.

Conclusions:

There was no repair of large osteochondral defects of the femoral condyles.
Subject(s)

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Index: LILACS (Americas) Main subject: Cartilage, Articular / Transplants / Animal Experimentation Limits: Animals Language: Spanish Year: 2013 Type: Thesis

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Index: LILACS (Americas) Main subject: Cartilage, Articular / Transplants / Animal Experimentation Limits: Animals Language: Spanish Year: 2013 Type: Thesis