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More than just a common cold: endemic coronaviruses OC43, HKU1, NL63, and 229E associated with severe acute respiratory infection and fatality cases among healthy adults
Veiga, Ana Beatriz Gorini da; Martins, Letícia Garay; Riediger, Irina; Mazetto, Alix; Debur, Maria do Carmo; Gregianini, Tatiana Schaffer.
  • Veiga, Ana Beatriz Gorini da; Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA). Department of Basic Health Sciences. Porto Alegre. BR
  • Martins, Letícia Garay; Rio Grande do Sul (Estado). Secretaria da Saúde. Centro Estadual de Vigilância em Saúde (CEVS). Porto Alegre. BR
  • Riediger, Irina; Paraná (Estado). Secretaria da Saúde. Laboratório Central de Saúde Pública (LACEN-PR). São José dos Pinhais. BR
  • Mazetto, Alix; Paraná (Estado). Secretaria da Saúde. Laboratório Central de Saúde Pública (LACEN-PR). São José dos Pinhais. BR
  • Debur, Maria do Carmo; Paraná (Estado). Secretaria da Saúde. Laboratório Central de Saúde Pública (LACEN-PR). São José dos Pinhais. BR
  • Gregianini, Tatiana Schaffer; Rio Grande do Sul (Estado). Secretaria da Saúde. Laboratório Central de Saúde Pública (LACEN-RS). Porto Alegre. BR
J. med. virol ; 92(10): 1-6, Aug. 2, 2020. tab
Article in English | LILACS, ColecionaSUS, CONASS, SES-RS | ID: biblio-1120884
Responsible library: BR1618.1
ABSTRACT
Respiratory viral infection can cause severe disease and hospitalization, especially among children, the elderly, and patients with comorbidities. In Brazil, the official surveillance system of severe acute respiratory infection (SARI) investigates influenza A (IAV) and B (IBV) viruses, respiratory syncytial virus (RSV), adenovirus (HAdV), and parainfluenza viruses (hPIV 1­3). In Rio Grande do Sul (RS), Brazil, many fatalities associated with SARI between 2013 and 2017 occurred among patients without underlying diseases and for whom the causative agent had not been identified using official protocols. This cross­sectional study analyzed the presence of coronaviruses (HCoV), bocavirus (HBoV), metapneumovirus (hMPV), and rhinovirus in patients who died of SARI despite not having comorbidities, and that were negative for IAV, IBV, RSV, HAdV, and hPIV. Nasopharyngeal aspirates/swabs from patients were used for nucleic acid extraction. The presence of HCoVs OC43, HKU1, NL63, and 229E; HBoV; hMPV; and rhinovirus was assessed by quantitative reverse transcription­polymerase chain reaction. Clinical data were also analyzed. Between 2013 and 2017, 16 225 cases of SARI were reported in RS; 9.8% of the patients died; 20% of all fatal cases were patients without comorbidities and for whom no pathogen was detected using standard protocols. Analysis of 271 of these cases identified HCoV in nine cases; HBoV, hMPV, and rhinovirus were detected in 3, 3, and 10 cases, respectively. Of note, patients infected with HCoV were adults. Results reinforce the importance of including coronaviruses in diagnostic panels used by official surveillance systems because besides their pandemic potential, endemic HCoVs are associated to severe disease in healthy adults.
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Full text: Available Index: LILACS (Americas) Main subject: Respiratory System / Coronavirus / Epidemiological Monitoring / Infections Type of study: Risk factors / Screening study Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male Language: English Journal: J. med. virol Year: 2020 Type: Article Institution/Affiliation country: Paraná (Estado)/BR / Rio Grande do Sul (Estado)/BR / Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)/BR

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Full text: Available Index: LILACS (Americas) Main subject: Respiratory System / Coronavirus / Epidemiological Monitoring / Infections Type of study: Risk factors / Screening study Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male Language: English Journal: J. med. virol Year: 2020 Type: Article Institution/Affiliation country: Paraná (Estado)/BR / Rio Grande do Sul (Estado)/BR / Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)/BR