Gene expression of collagen type I alpha 2 and its relationship with dental fluorosis
J. oral res. (Impresa)
;
7(6): 232-235, ago. 1, 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-1120975
ABSTRACT
Objective:
to compare the gene expression levels of collagen type I alpha 2 (COL1A2) in children with and without dental fluorosis.methods:
cross-sectional study involving 92 children between 5 and 12 years of age. socio-demographic characteristics, the presence of dental fluorosis by means of the Thylstrup-Fejerskov index, and gene expression analysis of COL1A2 in peripheral blood samples by reverse transcription polymerase chain reaction (RT-PCR) assays, were described. for the descriptive analysis, measures of central tendency, dispersion and proportions were used. differences between the groups (p<0.05) were established by the student t-test.results:
mean age was 8.6 (SD=1.9) years, 51.1 percent were female; 54 children were diagnosed with fluorosis and 38 without fluorosis; prevalence of dental fluorosis was 58.7 percent (95 percent CI 48.4 percent -68.9 percent). gene expression of COL1A2 was statistically significantly lower (p<0.05) in the participants with dental fluorosis.conclusion:
there are differences in the expression levels of the COL1A2 gene among the population under study. therefore, COL1A2 may be potentially involved in the development of dental fluorosis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Collagen Type I
/
Fluorosis, Dental
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Colombia
Language:
English
Journal:
J. oral res. (Impresa)
Journal subject:
Dentistry
Year:
2018
Type:
Article
Affiliation country:
Colombia
Institution/Affiliation country:
Universidad de Cartagena/CO
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