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A 12-year study of fungal infections in Rio Grande do Sul, southern Brazil
Fay, Vanessa da Silva; Gregianini, Tatiana Schaffer; Veiga, Ana Beatriz Gorini da; Gonçalves, Stela Maris Bottin; Rodrigues, Diana Mara; Bonamigo, Renan Rangel.
  • Fay, Vanessa da Silva; Rio Grande do Sul (Estado). Secretaria da Saúde. Laboratório Central de Saúde Pública (LACEN-RS). Porto Alegre. BR
  • Gregianini, Tatiana Schaffer; Rio Grande do Sul (Estado). Secretaria da Saúde. Laboratório Central de Saúde Pública (LACEN-RS). Porto Alegre. BR
  • Veiga, Ana Beatriz Gorini da; Programa de Pós-Graduação em Patologia. Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA). Porto Alegre. BR
  • Gonçalves, Stela Maris Bottin; Rio Grande do Sul (Estado). Secretaria da Saúde. Laboratório Central de Saúde Pública (LACEN-RS). Porto Alegre. BR
  • Rodrigues, Diana Mara; Rio Grande do Sul (Estado). Secretaria da Saúde. Laboratório Central de Saúde Pública (LACEN-RS). Porto Alegre. BR
  • Bonamigo, Renan Rangel; Programa de Pós-Graduação em Patologia. Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA). Porto Alegre. BR
Rev. iberoam. micol ; 36(2): 55-60, 2019. tab
Article in English | LILACS, ColecionaSUS, CONASS, SES-RS | ID: biblio-1121303
Responsible library: BR1618.1
ABSTRACT

Background:

The number of fungal infections has increased in recent years in Rio Grande do Sul (RS), Brazil. Epidemiological studies are important for proper control of infections.

Aims:

To evaluate the etiology of fungal infections in patients in RS, from 2003 to 2015.

Methods:

This is a retrospective and longitudinal study carried out at Mycology Department of Central Laboratory of RS; 13,707 samples were evaluated. The variables sex, age, site of infection, and etiologic agent were analyzed. Susceptibility of Candida to fluconazole was tested in samples collected in 2015from 51 outpatients.

Results:

Of the 13,707 samples, 840 cases (6.12%) of fungal infections were found and included in the analyses; female gender accounted for the 55.9% of the cases. The main fungus was Candida albicans (450 cases, 53.38%; p < 0.001). Onychomycosis was the most frequent infection in superficial mycoses. Systemic mycoses accounted for 54.05% of the cases, from which 68.8% occurred in males, mainly HIVpositive (33.11%), and the main etiologic agent in these cases was Cryptococcus neoformans (73.13%). Among 51 samples tested for susceptibility to fluconazole, 78.43% of Candida isolates were susceptible; 5.88% were susceptible in a dose-dependent manner, and 15.69% were resistant.

Conclusions:

C. albicans is a common cause of fungal infections in RS, accounting for half of the cases;resistance to antifungals was found in non-hospitalized patients. In addition, women seem to be moresusceptible to fungal infections than men, however men show more systemic mycoses than women. Thenails are the most common site of infection. (AU)
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Fungi / Mycoses Type of study: Observational study / Prevalence study / Risk factors Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: South America / Brazil Language: English Journal: Rev. iberoam. micol Year: 2019 Type: Article Institution/Affiliation country: Programa de Pós-Graduação em Patologia/BR / Rio Grande do Sul (Estado)/BR

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Full text: Available Index: LILACS (Americas) Main subject: Fungi / Mycoses Type of study: Observational study / Prevalence study / Risk factors Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: South America / Brazil Language: English Journal: Rev. iberoam. micol Year: 2019 Type: Article Institution/Affiliation country: Programa de Pós-Graduação em Patologia/BR / Rio Grande do Sul (Estado)/BR