Caracterización patogénica, clínica y diagnóstica de la pandemia por SARS-CoV-2 / Pathogenic, clinical and diagnostic characteristics of the SARS-CoV-2 pandemic
Rev. chil. infectol
;
37(3): 265-275, jun. 2020. tab
Article
in Spanish
| LILACS
| ID: biblio-1126119
RESUMEN
Resumen El SARS-CoV-2 es el agente patógeno responsable del COVID-19, enfermedad infecciosa que puede evolucionar desde un cuadro viral leve hasta la falla multiorgánica y muerte. Esta enfermedad se caracteriza por tener una tasa de transmisibilidad elevada, lo que ha permitido su diseminación por el mundo. No existen marcadores pronósticos claros que guíen la gravedad del cuadro; no obstante, hay elementos clínicos que podrían considerarse posibles predictores de gravedad. Conocer su estructura viral y patogenia ha posibilitado objetivar los pasos moleculares específicos que pueden ser blancos terapéuticos de variados fármacos, los cuales se mantienen en investigación y marcarán las directrices de futuros protocolos.
ABSTRACT
Abstract SARS-CoV-2 is the pathogen responsible for COVID-19, an infectious disease that can evolve from a mild viral illness to multiple organ failure and death. This disease is characterized by a high transmissibility rate, which has lead to its spread throughout the world. There are no clear prognostic markers to guide the severity of the condition; however, some clinical elements could be considered possible predictors of severity. Knowing its viral structure and pathogenesis has allowed to recognize specific molecular pathways candidates as therapeutic targets for various drugs, which are still under investigation and will set the guidelines for future protocols.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Pandemics
/
Betacoronavirus
Type of study:
Diagnostic study
/
Practice guideline
/
Prognostic study
/
Screening study
Limits:
Humans
Language:
Spanish
Journal:
Rev. chil. infectol
Journal subject:
Communicable Diseases
Year:
2020
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Clínico Universidad de Chile/CL
/
Universidad San Sebastián/CL
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