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Modelo de indução de osteoporose em coelhas - avaliação radiográfica / Rabbit osteoporosis induction model - radiographic evaluation
Araújo, F. R; Valente, F. L; Reis, E. C. C; Ermita, D. A. C. F; Sepúlveda, R. V; Borges, A. P. B.
  • Araújo, F. R; Universidade Federal de Viçosa. Viçosa. BR
  • Valente, F. L; Universidade Federal de Viçosa. Viçosa. BR
  • Reis, E. C. C; Universidade Federal de Viçosa. Viçosa. BR
  • Ermita, D. A. C. F; Universidade Federal de Viçosa. Viçosa. BR
  • Sepúlveda, R. V; Universidade Vila Velha. Vila Velha. BR
  • Borges, A. P. B; Universidade Federal de Viçosa. Viçosa. BR
Arq. bras. med. vet. zootec. (Online) ; 72(2): 633-636, Mar./Apr. 2020. ilus, graf
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1128494
ABSTRACT
In order to establish a bone loss induction model in rabbits to study osteoporosis, 18 rabbits underwent ovariectomy and received methylprednisolone 1mg/kg intramuscularly on alternate days for two weeks. Immediately before ovariectomy up to 42 days after methylprednisolone administration, radiographs of the right olecranon were taken in the mediolateral position to evaluate the radiographic optical density. Before the induction of osteoporosis, rabbits presented mean values of radiographic density of 2.305mm Al and at 42 days of 1.575mm Al. The values obtained were submitted to ANOVA for repeated measures that revealed a significant drop (P< 0.001) in the density over time, proving that the induction was able to trigger bone loss of these animals. With this, it can be affirmed that the adopted protocol was enough to provoke a significant bone loss, characterizing a valid model for the study of new treatments for osteoporosis.(AU)
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Full text: Available Index: LILACS (Americas) Main subject: Osteoporosis / Bone Regeneration / Bone Density Type of study: Practice guideline Limits: Animals Language: Portuguese Journal: Arq. bras. med. vet. zootec. (Online) Year: 2020 Type: Article Institution/Affiliation country: Universidade Federal de Viçosa/BR / Universidade Vila Velha/BR

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Full text: Available Index: LILACS (Americas) Main subject: Osteoporosis / Bone Regeneration / Bone Density Type of study: Practice guideline Limits: Animals Language: Portuguese Journal: Arq. bras. med. vet. zootec. (Online) Year: 2020 Type: Article Institution/Affiliation country: Universidade Federal de Viçosa/BR / Universidade Vila Velha/BR