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Adverse outcomes in SAR-CoV-2 (COVID-19) and SARS virus related pregnancies with probable vertical transmission
Bahadur, G; Homburg, R; Yoong, W; Singh, C; Bhat, M; Kotabagi, P; Acharya, S; Huirne, J; Doreski, PA; Lukaszuk, M; Muneer, A.
  • Bahadur, G; North Middlesex University Hospitals Trust. Obstetrics & Gynaecology Department. Reproductive Medicine Unit. London. GB
  • Homburg, R; Homerton University Hospital. Homerton Fertility Centre. London. GB
  • Yoong, W; North Middlesex University Hospitals Trust. Obstetrics & Gynaecology Department. Reproductive Medicine Unit. London. GB
  • Singh, C; North Middlesex University. London Neonatal and Peadiatric Unit. London. GB
  • Bhat, M; University Hospital Crosshouse. Ayrshire Fertility Unit. Kilmarnock Scotland Ayrshire Fertility Unit. Kilmarnock. GB
  • Kotabagi, P; North Middlesex University Hospitals Trust. Obstetrics & Gynaecology Department. Reproductive Medicine Unit. London. GB
  • Acharya, S; University Hospital Crosshouse. Ayrshire Fertility Unit. Kilmarnock Scotland Ayrshire Fertility Unit. Kilmarnock. GB
  • Huirne, J; University Medical Centers Amsterdam. Research Institute Reproduction and Development. Amsterdam. hungria
  • Doreski, PA; Fundacion Respirar. Buenos Aires. AR
  • Lukaszuk, M; Nowe Orlowo Medical Center. Gdynia. PL
  • Muneer, A; University College London Hospital. NIHR Biomedical Research Centre. London. GB
JBRA Assist Reprod ; 24(3): 351-357, 2020.
Article in English | LILACS, MMyP | ID: biblio-1128759
ABSTRACT
The global severe acute respiratory syndrome-related coronavirus SARS-CoV-2 (COVID-19) pandemic has had an unprecedented impact on all aspects of daily life and healthcare. Information on the infection risks for pregnant women and their offspring have so far been limited to small case series, until a large UK report on 427 SARS-CoV-2 infected pregnant women was published. Previous SARS epidemic experiences were drawn upon. Diagnostic use of real time polymerase chain reaction (RT-PCR) and IgG and IgM antibody tests are fraught with concerns of non-validation and false negative results, as are sampling methodologies. Virtually no information on controls accompany these reports. Infection of the mother and baby has serious implications for obstetric and neonatal care. Information on early and late stage pregnancy infection and the relationship to severity of infection on fetal development is both useful and clearly warranted. An increasing number of reports centre around mildly infected women showing no evidence of fetal infection while a few reports suggesting vertical transmission require further validation. Vertical transmission from mother to baby however small would have profound health implications for obstetric and neonatal care and fetal abnormalities. Some data suggesting intrapartum vertical transmission from mother to baby cannot be dismissed given the lack of controls and limitations of diagnostic viral tests. This analysis covers some key early reports addressing pregnancy outcomes following SARS-CoV-2 infection. (AU)
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Full text: Available Index: LILACS (Americas) Main subject: Pregnancy Complications / Risk Factors / Coronavirus Infections / Infectious Disease Transmission, Vertical / Betacoronavirus Type of study: Etiology study / Risk factors Language: English Journal: JBRA Assist Reprod Year: 2020 Type: Article Institution/Affiliation country: Fundacion Respirar/AR / Homerton University Hospital/GB / North Middlesex University Hospitals Trust/GB / North Middlesex University/GB / Nowe Orlowo Medical Center/PL / University College London Hospital/GB / University Hospital Crosshouse/GB / University Medical Centers Amsterdam/hungria

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Full text: Available Index: LILACS (Americas) Main subject: Pregnancy Complications / Risk Factors / Coronavirus Infections / Infectious Disease Transmission, Vertical / Betacoronavirus Type of study: Etiology study / Risk factors Language: English Journal: JBRA Assist Reprod Year: 2020 Type: Article Institution/Affiliation country: Fundacion Respirar/AR / Homerton University Hospital/GB / North Middlesex University Hospitals Trust/GB / North Middlesex University/GB / Nowe Orlowo Medical Center/PL / University College London Hospital/GB / University Hospital Crosshouse/GB / University Medical Centers Amsterdam/hungria