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Investigation of the role of rosmarinic acid treatment in regulating inflammation, cell damage, and angiogenesis in rat ovarian torsion and detorsion models
Deger, Ugur; Çavus, Yunus.
  • Deger, Ugur; Memorial Hospital. Department of Obstetrics and Gynecology. Diyarbakir. TR
  • Çavus, Yunus; Memorial Hospital. Department of Obstetrics and Gynecology. Diyarbakir. TR
Acta cir. bras ; 35(3): e202000304, 2020. tab, graf
Article in English | LILACS | ID: biblio-1130623
ABSTRACT
Abstract Purpose To investigate the protective effect of rosmarinic acid (RA) in ovarian ischemia/reperfusion injury using biochemical, histopathological, and immunohistochemical methods. Methods Wistar female rats (n = 32) were randomly divided into four groups control, ischemia, ischemia-reperfusion, and ischemia-reperfusion with RA. Rosmarinic acid was given at a dose of 50 mg/kg by oral gavage three hours after reperfusion. Malondialdehyde (MDA) levels and glutathione peroxidase (GSH-Px) activities were determined in the ovary tissue homogenates for each rat. Results In the ischemia-reperfusion with RA group, the epithelial cells are regularly regulated at the periphery, and the degenerative changes in preantral and antral follicle cells are reduced. Follicle cells and cells in the corpus luteum showed a decrease in vascular endothelial growth factor (VEGF) expression, while VEGF demonstrated a positive reaction in vascular endothelial cells and stromal cells. The TNF-α expression due to the decreased degenerative effect and inflammation was positive in the macrophage cells. The expression of caspase-3 as an apoptosis change was negative in antral follicle cells and granular cells around the antral follicle. Conclusion Different doses of RA may be useful in preventing ischemic damage after vascularization, inflammation, and apoptotic development after ischemia/reperfusion.
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Full text: Available Index: LILACS (Americas) Main subject: Ovarian Diseases / Reperfusion Injury / Cinnamates / Vascular Endothelial Growth Factor A / Depsides Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Memorial Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Ovarian Diseases / Reperfusion Injury / Cinnamates / Vascular Endothelial Growth Factor A / Depsides Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Memorial Hospital/TR