Therapeutic effects of vitamin D on acetic acid-induced colitis in rats
Acta cir. bras
;
35(4): e202000404, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1130634
ABSTRACT
Abstract Purpose To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. Methods A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups control group (n8), colitis group (n8), calcitriol administered group (n8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 µg/kg for 5 days. Results Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p<0.01). In the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p <0.000). Conclusion The findings suggest that calcitriol may be an agent that could be used in acute colitis treatment.
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Index:
LILACS (Americas)
Main subject:
Calcitriol
/
Colitis
/
Anti-Inflammatory Agents
Type of study:
Controlled clinical trial
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2020
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Ege University/TR
/
Istanbul Medipol University/TR
/
Izmir Katip Çelebi University/TR
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