Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride
Acta cir. bras
;
35(5): e202000507, 2020. graf
Article
in English
| LILACS
| ID: biblio-1130640
ABSTRACT
Abstract Purpose To develop a new wound dressing composed of alginate and Aloe vera gel and cross-linked with zinc ions. Methods The aloe-alginate film was characterized using scanning electron microscopy (SEM), swelling profile, mechanical properties, polysaccharide content and X-ray diffraction (XRD). Thirty Wistar rats were divided in two groups a) treated with aloe-alginate film and b) control (treated with sterile gauze). Wound contraction measurements and hystological analysis were performed on 7th, 14th and 21st days after wound surgery. Results The aloe-alginate film presented adequated mechanical resistance and malleability for application as wound dressing. There was no statistical difference in wound contraction between two groups. Histological assay demonstrated that aloe-alginate film presented anti-inflammatory activity, stimulated angiogenesis on proliferative phase and a more significant increased in collagen type I fibers and decreased type III fibers which promoted a mature scar formation when compared to control. Conclusions The aloe-alginate film showed adequate physicochemical characteristics for wound dressing applications. The in vivo assay demonstrated that aloe-alginate film enhanced the healing process of incisional skin wounds.
Full text:
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Index:
LILACS (Americas)
Main subject:
Wound Healing
/
Chlorides
/
Zinc Compounds
/
Plant Preparations
/
Alginates
/
Aloe
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Technology Institute of Paraná/BR
/
UEPG/BR
/
Universidade Estadual de Ponta Grossa/BR
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